6-METHYLAMINOPURINE 9-RIBOFURANOSIDE Chemical Properties

Melting point:

172 °C

Boiling point:

649.1±65.0 °C(Predicted)

Density 

1.85±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)

pka

13.12±0.70(Predicted)

form 

Powder

color 

White to off-white

PH

4.0

λmax

262 (pH 1)；266 (pH 7)

Stability:

Hygroscopic

6-METHYLAMINOPURINE 9-RIBOFURANOSIDE Usage And Synthesis

Description

N⁶-Methyladenosine is an adenosine analog. It inhibits epinephrine-induced contraction of isolated guinea pig ileum and thoracic aorta when used at a concentration of 10 μM. N⁶-Methyladenosine (1 mg/kg, i.v.) decreases arterial blood pressure and renal blood flow and increases peripheral resistance in anesthetized dogs. It also inhibits tumor growth in the C3H/ST and C3HB/ST mouse models of spontaneous mammary adenocarcinomas. N⁶-Methyladenosine is also the most prevelant mRNA modification in eukaryotes and has roles in cell viability and development.

Uses

N6-Methyladenosine is the most common internal modification of eukaryotic mRNA. The result of this modification is specifically recognized mRNA in the cytoplasm which regulates mRNA stability.N6-Methyladenosine is made when a protein complex containin the writer enzyme METTL3 adds a methyl group to adenosine. Two different eraser enzymes ALKBH5 and FTO can remove a methyl group to turn m6A bach into adenosine.

Definition

ChEBI: A methyladenosine compound with one methyl group attached to N6 of the adenine nucleobase.

6-METHYLAMINOPURINE 9-RIBOFURANOSIDE(1867-73-8)Related Product Information

• c-di-AMP
• ADENOSINE-2':3'-CYCLIC MONOPHOSPHATE, SODIUM SALT
• INDEX NAME NOT YET ASSIGNED
• [5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-oxolan-2-yl]methoxyphosphonic acid
• 2'-O-Methyladenosine
• ADENOSINE 2' -& 3'-MONOPHOSPHATE FREE
• ADP
• [(2R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxy-oxolan-2-yl]me thoxyphosphonic acid
• 2'-Deoxyadenosine
• 3'-ADENYLIC ACID
• P1,P2-di(adenosine-5')pyrophosphate sodium salt
• 2-amino-2-deoxy-beta-arabinofuranosyladenine
• 2'-Deoxyadenosine-5'-triphosphate, trisodiuM salt
• 2'-Adenylic acid, 3',5'-bis(dihydrogen phosphate) (9CI)
• Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-[1-(dimethylamino)ethylidene]- (9CI)
• N6-BENZYLADENOSINE
• N6-ISOPENTENYLADENOSINE-D6
• KINETIN RIBOSIDE