Chelerythrine Chemical Properties

Melting point:

195-205°C

Boiling point:

496.37°C (rough estimate)

Density 

1.2985 (rough estimate)

refractive index 

1.5614 (estimate)

storage temp. 

Desiccate at -20°C

solubility 

Chloroform (Slightly, Sonicated), DMSO (Slightly, Sonicated), Methanol (Slightly）

form 

Solid

color 

Light Yellow to Dark Orange

Stability:

Hygroscopic

LogP

-0.401 (est)

CAS DataBase Reference

34316-15-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22

Safety Statements 

36/37

Chelerythrine Usage And Synthesis

Description

Chelerythrine chloride is the chloride form of Chelerythrine chloride which is a benzophenanthridine alkaloid isolated from the plant Chelidonium majus (greater celandine). It is a kind of potent, selective, and cell-permeable protein kinase C inhibitor, an efficient antagonist of G-protein-coupled CB1 receptors, and an independent activator of MAPK pathways. It has a wide range of biological activities including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. It has reported of that it is capable of inducing apoptosis in HL-60 human promyelocytic leukemia cells and several other cancer cell lines. The underlying mechanism is through its effects of inhibiting the binding of BclXL to Bax or Bad.

References

https://en.wikipedia.org/wiki/Chelerythrine
https://www.scbt.com/scbt/product/chelerythrine-chloride-3895-92-9
https://www.tocris.com/dispprod.php?ItemId=2342#.WQmZVVNsgZQ

Uses

Chelerythrine Chloride is a cell permeable protein kinase C (PKC) inhibitor.

Definition

ChEBI: A benzophenanthridine alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae.

Biological Activity

Potent, cell-permeable inhibitor of protein kinase C (IC 50 = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of BclXL to Bak (IC 50 = 1.5 μ M) or Bad proteins and stimulates apoptosis.

Purification Methods

Chelerythrine crystallises from CHCl3 on addition of MeOH [Manske Can J Res 21B 140 1943, UV: Hruban et al. Coll Czech Chem Commun 35 3420 1970]. The pseudo base is colourless while the salts are yellow in aqueous solution and are fluorescent.

Chelerythrine(34316-15-9)Related Product Information

• METSULFURON METHYL
• Methylparaben
• Zinc chloride
• Choline chloride
• Potassium chloride
• Sodium chloride
• Methyl acetate
• Methyl acrylate
• Calcium chloride
• Bensulfuron methyl
• Oxalyl chloride
• Thiophanate-methyl
• Kresoxim-methyl
• Thionyl chloride
• Ammonium chloride
• Methyl
• Parathion-methyl
• CHELERYTHRINE CHLORIDE(RG)