THR-ARG-SER-ALA-TRP
THR-ARG-SER-ALA-TRP Basic information
- Product Name:
- THR-ARG-SER-ALA-TRP
- Synonyms:
-
- OSTEOSTATIN (1-5) (HUMAN, BOVINE, DOG, HORSE, MOUSE, RABBIT, RAT)
- OSTEOSTATIN (HUMAN, RAT)
- PARATHYROID HORMONE-RELATED PROTEIN (107-111)
- PARATHYROID HORMONE RELATED PROTEIN (107-111), HUMAN, RAT
- PARATHYROID HORMONE RELATED PEPTIDE (107-111)
- LYS-HIS-LEU-ASN-SER-MET-GLU-ARG-VAL-GLU-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-PHE: KHLNSMERVEWLRKKLQDVHNF
- pTH-Related Protein (107-111) (huMan, bovine, dog, horse, Mouse, rabbit, rat), HypercalceMia of Malignancy Factor (107-111) (huMan, bovine, dog, horse, Mouse, rabbit, rat), pTH-rP (107-111) (huMan, bovine, dog, horse, Mouse, rabbit, rat)
- Osteostatin, Parathyroid hormone-related protein (107-111), PTHrP (107-111), Thr-Arg-Ser-Ala-Trp
- CAS:
- 138949-73-2
- MF:
- C27H41N9O8
- MW:
- 619.67
- Mol File:
- 138949-73-2.mol
THR-ARG-SER-ALA-TRP Chemical Properties
- storage temp.
- -15°C
- form
- Solid
- Sequence
- Thr-Arg-Ser-Ala-Trp
THR-ARG-SER-ALA-TRP Usage And Synthesis
Uses
Osteostatin, a fragment of parathyroid hormone-related protein (PTHrP) 107-111, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis, inhibits collagen-induced arthritis and inhibits osteoclastic bone resorption directly. Osteostatin can be used for inflammation and immunology research[1][2][3][4].
in vivo
Osteostatin (80 or 120 μg/kg,; after the onset of disease s.c. every day for 13 days) decreases the severity of arthritis as well as cartilage and bone degradation[4].
| Animal Model: | Collagen-induced arthritis in male DBA/1 mice[4] |
| Dosage: | 80 or 120 μg/kg |
| Administration: | After the onset of disease s.c. every day for 13 days |
| Result: | Reduced serum IgG2a levels as well as T cell activation, with the downregulation of RORγt+CD4+ T cells and upregulation of FoxP3+CD8+ T cells in lymph nodes. Decreased the levels of key cytokines, such as interleukin (IL)-1β, IL-2, IL-6, IL-17, and tumor necrosis factor-α in mice paws, whereas enhanced IL-10. |
References
[1] Fenton AJ, et.al. A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP[107-111]. Endocrinology. 1991 Dec;129(6):3424-6. DOI:10.1210/endo-129-6-3424
[2] Ibá?ez L, et.al. Osteostatin Inhibits M-CSF+RANKL-Induced Human Osteoclast Differentiation by Modulating NFATc1. Int J Mol Sci. 2022 Aug 1;23(15):8551. DOI:10.3390/ijms23158551
[3] Lozano D, et.al. Osteostatin-loaded bioceramics stimulate osteoblastic growth and differentiation. Acta Biomater. 2010 Mar;6(3):797-803. DOI:10.1016/j.actbio.2009.08.033
[4] Nácher-Juan J, et.al. Osteostatin Inhibits Collagen-Induced Arthritis by Regulation of Immune Activation, Pro-Inflammatory Cytokines, and Osteoclastogenesis. Int J Mol Sci. 2019 Aug 7;20(16):3845. DOI:10.3390/ijms20163845
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