3-FLUOROBENZHYDRAZIDE Chemical Properties

Melting point:

139-143 °C (lit.)

Density 

1.272±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

11.78±0.10(Predicted)

form 

Crystalline Powder

color 

White to off-white

CAS DataBase Reference

499-55-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36/37/39-36

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2928009090

3-FLUOROBENZHYDRAZIDE Usage And Synthesis

Uses

3-FLUOROBENZHYDRAZIDE can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

Hydrazides (30-58) were synthesized by one pot conventionalmethod24 Benzoic acid or its derivative (10 mmol) was dissolvedin ethanol (20 mL). Sulfuric acid (3 N, 2 mL) was added and thereaction contents were refluxed for six hours. The reaction wasmonitored with TLC. After the completion of the reaction, the reactionmixture was neutralized by adding solid NaHCO3, and filteredto remove excess of NaHCO3. In the neutralized reaction mixture which contains ethyl ester, hydrazine monohydrate (1.5 mL,3 mmol) was added and refluxed for 3-6 h to complete the reaction.Ethanol and unreacted hydrazine were removed by distillationupto 1/3 volume. The reaction contents were cooled, filteredand recrystallized from methanol to obtain the desired hydrazidecrystals (see Supporting information).

3-FLUOROBENZHYDRAZIDE(499-55-8)Related Product Information

• 3,4-DIFLUOROBENZOIC ACID HYDRAZIDE
• 2-Fluorobenzohydrazide
• 4-Fluorobenzhydrazide98%,p-Fluorobenzhydrazide,4-FLUOROBENZHYDRAZIDE
• 3-FLUOROBENZHYDRAZIDE
• 3,5-DIFLUOROBENZHYDRAZIDE
• 3-fluoro-4-methylbenzohydrazide
• 7-FLUORO-2,4-BIS(4-FLUOROPHENYL)-1(2H)-PHTHALAZINONE
• 5-fluoro-2-nitrobenzohydrazide
• 2-(4-BROMOPHENYL)-7-FLUORO-4-(4-FLUOROPHENYL)-1(2H)-PHTHALAZINONE
• 5-ETHYL-3-PHENYL-6-(4,5,6,7-TETRAFLUORO-3-OXO-1,3-DIHYDRO-INDAZOL-2-YL)-PIPERIDINE-2,4-DIONE
• 7-FLUORO-4-(4-FLUOROPHENYL)-2-[4-(TRIFLUOROMETHOXY)PHENYL]-1(2H)-PHTHALAZINONE
• 2,4,5-trifluoro-3-hydroxybenzohydrazide
• 2,3-DIFLUOROBENZOIC ACID HYDRAZIDE
• ETHYL 5-FLUORO-3-OXO-2,3-DIHYDRO-1H-INDAZOLE-1-CARBOXYLATE
• 2-bromo-5-fluorobenzohydrazide
• 2-(4-CHLOROPHENYL)-7-FLUORO-4-(4-FLUOROPHENYL)-1(2H)-PHTHALAZINONE
• 2,3,4-trifluorobenzohydrazide
• 7-FLUORO-4-(4-FLUOROPHENYL)-2-[4-(TRIFLUOROMETHYL)PHENYL]-1(2H)-PHTHALAZINONE