2-Fluorobenzohydrazide Chemical Properties

Melting point:

70-74 °C (lit.)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

soluble in Methanol

form 

Powder or Crystalline Powder

color 

White to pale brown

CAS DataBase Reference

446-24-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2928009090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Fluorobenzohydrazide Usage And Synthesis

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 26, p. 257, 1989 DOI: 10.1002/jhet.5570260147

Synthesis

GENERAL METHODS: 2-Fluorophenylidene hydrazine was synthesized routinely by one-pot method (30-58% yield). Ethyl o-fluorobenzoate (10 mmol) was dissolved in ethanol (20 mL). 3N sulfuric acid (2 mL) was added to the solution, followed by refluxing the reaction mixture for 6 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was neutralized with solid NaHCO3 and excess NaHCO3 was removed by filtration.To the neutralized reaction mixture, hydrazine monohydrate (1.5 mL, 3 mmol) was added and refluxing was continued for 3-6 h to ensure complete reaction. The ethanol and unreacted hydrazine monohydrate were concentrated to 1/3 of the original volume by distillation.The reaction mixture was cooled to room temperature, the resulting solid was filtered and recrystallized from methanol to give crystals of the target product, 2-fluorophenylidenehydrazine (see Supporting Information for specific data).

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 17, p. 6014 - 6024
[2] Journal of the American Chemical Society, 1950, vol. 72, p. 1806
[3] Journal of Agricultural and Food Chemistry, 2003, vol. 51, # 1, p. 152 - 155
[4] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 8, p. 2278 - 2282
[5] Journal of Medicinal Chemistry, 2010, vol. 53, # 20, p. 7392 - 7404

2-Fluorobenzohydrazide(446-24-2)Related Product Information

• 2,6-Difluorobenzoyl hydrazine
• 2-Fluorobenzohydrazide
• 4-FLUOROBENZHYDRAZIDE,4-Fluorobenzhydrazide98%,p-Fluorobenzhydrazide
• 2,4-DIFLUOROBENZOIC ACID HYDRAZIDE
• 3-Fluorobenzhydrazide 98%,3-Fluorobenzhydrazide98%,3-FLUOROBENZHYDRAZIDE
• 2,3-DIFLUOROBENZOIC ACID HYDRAZIDE
• SALOR-INT L175307-1EA
• 2-FLUORO-N'-METHYL-N'-[2-(TRIFLUOROMETHYL)-4-QUINAZOLINYL]BENZENECARBOHYDRAZIDE
• N'-(2,6-DIFLUOROBENZOYL)-8-METHYL-8H-THIENO[2,3-B]INDOLE-2-CARBOHYDRAZIDE
• SALOR-INT L273457-1EA
• SALOR-INT L460249-1EA
• N'-(2,6-DIFLUOROBENZOYL)-2-(1H-PYRROL-1-YL)BENZENECARBOHYDRAZIDE
• 2,5-DIFLUOROBENZOIC ACID HYDRAZIDE
• SALOR-INT L403636-1EA
• 2,6-DIFLUORO-N'-[1-METHYL-2,2-DIOXO-2,3-DIHYDRO-2LAMBDA6-THIENO[3,2-C][1,2]THIAZIN-4(1H)-YLIDEN]BENZENECARBOHYDRAZIDE
• SALOR-INT L384593-1EA
• 2,6-DIFLUORO-N'-METHYL-N'-[4-METHYL-3-(METHYLSULFONYL)-6-PHENYL-2-PYRIDINYL]BENZENECARBOHYDRAZIDE
• SALOR-INT L177377-1EA