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Tripeptide-1

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Tripeptide-1 Basic information

Product Name:
Tripeptide-1
Synonyms:
  • H-GLY-HIS-LYS-OH ACETATE SALT
  • H-GLY-HIS-LYS-OH ACOH
  • GLY-HIS-LYS ACETATE
  • GLY-HIS-LYS ACETATE SALT
  • GLY-HIS-LYS ACOH H2O
  • GLYCYL-L-HISTIDYL-L-LYSINE ACETATE
  • LIVER CELL GROWTH FACTOR
  • LIVER CELL GROWTH FACTOR ACETATE SALT
CAS:
72957-37-0
MF:
C16H28N6O6
MW:
400.44
EINECS:
277-125-4
Product Categories:
  • Amino Acid Derivatives
  • 72957-37-0
Mol File:
72957-37-0.mol
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Tripeptide-1 Chemical Properties

storage temp. 
-20°C
form 
powder
color 
white
biological source
synthetic (organic)
Water Solubility 
H2O: soluble 0.5mg/mL, clear, colorless
Sequence
Gly-His-Lys
InChI
InChI=1/C14H24N6O4.C2H4O2/c15-4-2-1-3-10(14(23)24)20-13(22)11(19-12(21)6-16)5-9-7-17-8-18-9;1-2(3)4/h7-8,10-11H,1-6,15-16H2,(H,17,18)(H,19,21)(H,20,22)(H,23,24);1H3,(H,3,4)/t10-,11-;/s3
InChIKey
MGNUTAFMLGJBGV-ACMTZBLWSA-N
SMILES
C(=O)(O)C.[C@@H](NC(=O)CN)(C(=O)N[C@H](C(=O)O)CCCCN)CC1N=CNC=1 |&1:4,13,r|
CAS DataBase Reference
72957-37-0(CAS DataBase Reference)
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Safety Information

WGK Germany 
3

MSDS

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Tripeptide-1 Usage And Synthesis

Description

Tripeptide-1 is a small peptide composed of three amino acids  (glycine-histidine-lysine or GHK) and is known for type I collagen fragments. When collagen fragment peptides (GHK) are added, it may mistakenly lead the skin to think that collagen has been broken down, resulting in more collagen. Therefore, tripeptide-1 is believed to stimulate collagen production in the skin. More collagen will reduce wrinkles on the face, which will improve the condition of the skin.

Chemical Properties

White powder

Uses

Liver Cell Growth Factor

Uses

Gly-His-Lys acetate salt has been used:

  • individually or as a complex with copper to test its effect on cytokines production in the human normal fibroblasts cell lines
  • as a model peptide in N,N-dimethyl-N-methacryloxyethyl-N-(3-sulfopropyl)ammonium betaine based capillary electrophoresis separation studies
  • as a component of Coon′s modified Ham′s F-12 medium for culturing Fischer rat thyroid follicular cell line, FRTL-5

General Description

Gly-His-Lys is a tripeptide present at ~200ng/ml in association with α-globulin and albumin, in human blood plasma.

Biochem/physiol Actions

Gly-His-Lys (GHK) acetate salt displays affinity towards copper(II) ions. This property enables GHK to modulate the copper intake into cells. GHK is also involved in quenching toxic by-products generated by lipid peroxidation.

in vitro

In an enzyme assay, the liver growth factor, Tripeptide-1, was hydrolyzed by an aminotripeptidase purified from rat brain cytosol[1].

in vivo

Tripeptide-1 (1% in saline; dose = 10 mg/kg) was injected into the tail vein of male rats (number not specified). Blood samples were collected prior to dosing and for up to 60 minutes post-dosing. Plasma concentration-time profiles of Tripeptide-1 and its l-histidyl-l-lysine metabolite indicated that neither was detected in predose plasma samples. However, after intravenous (IV) injection, Tripeptide-1 was rapidly degraded to l histidyl-l-lysine, rapidly eliminated from circulating blood. It has been reported that Tripeptide-1 is unstable in human plasma and is rapidly degraded by aminopeptidases[1].

References

[1] Wilbur Johnson. “Safety Assessment of Tripeptide-1, Hexapeptide-12, Their Metal Salts and Fatty Acyl Derivatives, and Palmitoyl Tetrapeptide-7 as Used in Cosmetics.” International Journal of Toxicology 37 1 (2018): 102S–90S.

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