Tripeptide-10 citrulline Chemical Properties

Boiling point:

965.2±65.0 °C(Predicted)

Density 

1.252±0.06 g/cm3(Predicted)

pka

4.15±0.10(Predicted)

InChIKey

UKVZHOYDLCJTIU-VPRSOUQONA-N

SMILES

C(NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)N)(=O)[C@H](CCCNC(N)=O)N |&1:4,5,12,20,28,r|

Tripeptide-10 citrulline Usage And Synthesis

Benifits in Skin

Tripeptide-10 Citrulline, or Decorinyl, is a tetrapeptide engineered in 2008 from decorin, whose peptide chain follows the +, –, 0, + charge pattern shown to be necessary for the binding of decorin to collagen. Not only does Tripeptide-10 Citrulline help regulate fibrillogenesis, it also regulates collagen fiber dimensions and uniformity, making this oligopeptide a good candidate for maintaining elasticity of skin and reducing wrinkles. A single-blinded parallel group controlled trial compared cream containing Tripeptide-10 Citrulline to placebo.

Description

Tripeptide-10 Citrulline (also known under the trade name Decorinyl?) is a brilliant new collagen organizing tetrapeptide that mimics decorin, improving collagen structures and restoring the skin's suppleness and resiliency. Thanks to decorin-like action, it regulates the fibrillogenesis process and collagen fibril dimensions.

Definition

Tripeptide-10 Citrulline is a new cosmetic active, designed as a substitute of decorin, that specifically targets collagen fibre organization to regulate collagen fibrillogenesis.

Biological Functions

Tripeptide-10 Citrulline ensures uniformity in fibril diameter and increases skin suppleness. Due to its good cohesion of collagen fibres, Tripeptide-10 Citrulline is widely used in anti-aging cosmetic products.

General Description

Citrulline is an organic compound and amino acid that is extracted from the skin of the watermelon, among other things. Like all amino acids it has water-binding properties and is therefore used in skin care cosmetics as moisturizer.

Mechanism of action

The aging process makes notable changes in the skin proteins. Decorin is an essential protein in the skin that controls collagen aggregation, equalizes fibril diameters, and maintains a normal packing. Unfortunately, the changes also affect decorin that becomes truncated and loses its effectiveness over time. This modified form (non-functional) of decorin, missing in young skin, lacks parts that can interact with collagen. As a result, it leaves a considerable negative effect on the skin's firmness and elasticity, resulting in morphologic changes in collagen organization in the mature skin.

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