4-(Difluoromethoxy)nitrobenzene
4-(Difluoromethoxy)nitrobenzene Basic information
- Product Name:
- 4-(Difluoromethoxy)nitrobenzene
- Synonyms:
-
- BUTTPARK 45\10-48
- Anisole,α,α-difluoro-p-nitro-
- Benzene,1-(difluoromethoxy)-4-nitro-
- Difluoromethyl4-nitrophenylether
- p-Nitrophenyldifluoromethylether
- 1-(DIFLUOROMETHOXY)-4-NITROBENZENE
- 4-(DIFLUOROMETHOXY)NITROBENZENE
- 4-NITRO-ALPHA,ALPHA-DIFLUOROANISOLE
- CAS:
- 1544-86-1
- MF:
- C7H5F2NO3
- MW:
- 189.12
- Product Categories:
-
- Building Blocks
- Chemical Synthesis
- Nitro Compounds
- Nitrogen Compounds
- Organic Building Blocks
- Mol File:
- 1544-86-1.mol
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4-(Difluoromethoxy)nitrobenzene Chemical Properties
- Melting point:
- 37-40 °C (lit.)
- Boiling point:
- 108 °C
- Density
- 1.384±0.06 g/cm3(Predicted)
- Flash point:
- >230 °F
- storage temp.
- 2-8°C
- form
- powder to lump
- color
- Light yellow to Brown to Dark green
- FreezingPoint
- 31.0 to 34.0 ℃
- CAS DataBase Reference
- 1544-86-1(CAS DataBase Reference)
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Safety Information
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36/37
- RIDADR
- 3276
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29049090
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
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4-(Difluoromethoxy)nitrobenzene Usage And Synthesis
Chemical Properties
Pale Yellow Crystal.
Uses
4-(Difluoromethoxy)nitrobenzene is an industrial chemical that can be used to make 4-fluoro-3-pyridinol (F3P), a compound that has potential as a new drug for the treatment of cancer. The synthesis of F3P begins with the reaction of 4-(difluoromethoxy)nitrobenzene and potassium hydroxide in methanol, which yields 4-fluoro-3-hydroxypyridine. This product is then reacted with ammonia gas and pyridine to yield F3P. The final step involves heating the product at high temperature with nitric acid, which yields nitrobenztriazole.
General Description
4-(Difluoromethoxy)nitrobenzene (1-(difluoromethoxy)-4-nitrobenzene) can be synthesized by reacting 4-nitrophenol with KOH, water and methanol.
4-(Difluoromethoxy)nitrobenzeneSupplier
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4-(Difluoromethoxy)nitrobenzene(1544-86-1)Related Product Information
- 2,2-DIFLUORO-5-NITRO-1,3-BENZODIOXOLE
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- 4-(Trifluoromethoxy)nitrobenzene
- 2-BROMO-4-NITRO(TRIFLUOROMETHOXY)BENZENE
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- 2-(DIFLUOROMETHOXY)NITROBENZENE,2-(Difluoromethoxy)nitrobenzene 97%,2-(Difluoromethoxy)nitrobenzene97%
- 3-(DIFLUOROMETHOXY)NITROBENZENE
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- Anisole
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