Basic information Safety Supplier Related

4-(Difluoromethoxy)nitrobenzene

Basic information Safety Supplier Related

4-(Difluoromethoxy)nitrobenzene Basic information

Product Name:
4-(Difluoromethoxy)nitrobenzene
Synonyms:
  • BUTTPARK 45\10-48
  • Anisole,α,α-difluoro-p-nitro-
  • Benzene,1-(difluoromethoxy)-4-nitro-
  • Difluoromethyl4-nitrophenylether
  • p-Nitrophenyldifluoromethylether
  • 1-(DIFLUOROMETHOXY)-4-NITROBENZENE
  • 4-(DIFLUOROMETHOXY)NITROBENZENE
  • 4-NITRO-ALPHA,ALPHA-DIFLUOROANISOLE
CAS:
1544-86-1
MF:
C7H5F2NO3
MW:
189.12
Product Categories:
  • Building Blocks
  • Chemical Synthesis
  • Nitro Compounds
  • Nitrogen Compounds
  • Organic Building Blocks
Mol File:
1544-86-1.mol
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4-(Difluoromethoxy)nitrobenzene Chemical Properties

Melting point:
37-40 °C (lit.)
Boiling point:
108 °C
Density 
1.384±0.06 g/cm3(Predicted)
Flash point:
>230 °F
storage temp. 
2-8°C
form 
powder to lump
color 
Light yellow to Brown to Dark green
FreezingPoint 
31.0 to 34.0 ℃
CAS DataBase Reference
1544-86-1(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
26-36/37
RIDADR 
3276
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29049090

MSDS

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4-(Difluoromethoxy)nitrobenzene Usage And Synthesis

Chemical Properties

Pale Yellow Crystal.

Uses

4-(Difluoromethoxy)nitrobenzene is an industrial chemical that can be used to make 4-fluoro-3-pyridinol (F3P), a compound that has potential as a new drug for the treatment of cancer. The synthesis of F3P begins with the reaction of 4-(difluoromethoxy)nitrobenzene and potassium hydroxide in methanol, which yields 4-fluoro-3-hydroxypyridine. This product is then reacted with ammonia gas and pyridine to yield F3P. The final step involves heating the product at high temperature with nitric acid, which yields nitrobenztriazole.

General Description

4-(Difluoromethoxy)nitrobenzene (1-(difluoromethoxy)-4-nitrobenzene) can be synthesized by reacting 4-nitrophenol with KOH, water and methanol.

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