(DIFLUOROMETHOXY)BENZENE Chemical Properties

Boiling point:

98 °C

Density 

1.2

refractive index 

1.45

Flash point:

43.1±19.0℃

storage temp. 

Sealed in dry,Room Temperature

Specific Gravity

1.200

Appearance

Colorless to light yellow Liquid

λmax

270nm(EtOH)(lit.)

CAS DataBase Reference

458-92-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

F

Risk Statements 

10

Safety Statements 

16-24/25-23

RIDADR 

1993

HazardClass 

FLAMMABLE

PackingGroup 

III

HS Code 

29093090

(DIFLUOROMETHOXY)BENZENE Usage And Synthesis

Chemical Properties

Clear colorless liquid

Synthesis

At room temperature, 0.28 g (0.003 mol) of phenol, 1.7 g (0.03 mol) of potassium hydroxide (KOH), an appropriate amount of water, and dioxane were added as solvents to a 50 mL round bottom flask. The reaction mixture was heated to 50°C, followed by the passage of trifluoromethane gas bubbling through the reaction solution for 2 hours. After completion of the reaction, the mixture was stirred at 50 °C overnight. The yield of difluoromethoxybenzene was calculated to be 70% by 19F NMR analysis (Figures 1 and 2 show the 19F NMR decoupling and proton coupling spectra of the reaction mixture and the purified difluoromethoxybenzene, respectively), using the 19F NMR integral signal of the HF2CO group as an internal standard.

References

[1] Patent: WO2014/113412, 2014, A1. Location in patent: Page/Page column 4
[2] Journal of Organic Chemistry, 2013, vol. 78, # 17, p. 8904 - 8908

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