2-(Trifluoromethoxy)bromobenzene Chemical Properties

Boiling point:

158-160 °C(lit.)

Density 

1.62 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.464(lit.)

Flash point:

140 °F

storage temp. 

Sealed in dry,Room Temperature

form 

clear liquid

color 

Colorless to Light yellow

BRN 

1947768

CAS DataBase Reference

64115-88-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39-37

RIDADR 

UN1993

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

3

PackingGroup 

III

HS Code 

29093090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-(Trifluoromethoxy)bromobenzene Usage And Synthesis

General Description

1-Bromo-2-(trifluoromethoxy)benzene can be prepared from (trifluoromethoxy)benzene.

Synthesis

In a glove box, KF (78.4 mg, 1.35 mmol, 4.5 eq.) was added to a 20 mL polyethylene (PE) plastic tube. Subsequently, dicyclohexane-18-crown-6 (503 mg, 1.35 mmol, 4.5 eq.) and 6. Next, ethylidene precursor (0.3 mmol, 1.0 eq.), 1-bromophenylacetylene (218 mg, 1.2 mmol, 4.0 eq.) or perfluorohexyl bromide (479 mg, 1.2 mmol, 4.0 eq.) or pentafluorophenyl bromide ( 296 mg, 1.2 mmol, 4.0 equiv) and trifluoromethyl benzoate (171 mg, 0.9 mmol, 3.0 equiv). The reaction tube was sealed and the reaction was carried out at room temperature for 12 hours. At the end of the reaction, the F-spectral yield was first determined by 19F NMR. Finally, the reaction mixture was filtered, dried and purified directly by column chromatography.

References

[1] Patent: CN108516935, 2018, A. Location in patent: Paragraph 0166; 0167; 0168; 0169; 0170; 0171
[2] Journal of the American Chemical Society, 2018, vol. 140, # 22, p. 6801 - 6805

2-(Trifluoromethoxy)bromobenzene(64115-88-4)Related Product Information

• 4-(Trifluoromethoxy)chlorobenzene
• 2-Methylbenzotrifluoride
• 3-(Trifluoromethoxy)aniline
• 4-(Trifluoromethoxy)benzaldehyde
• 2-Fluorobenzoyl chloride
• 4'-(Trifluoromethoxy)acetophenone
• 4-Bromofluorobenzene
• 2-Bromofluorobenzene
• Guaiacol
• 2-(Trifluoromethyl)benzaldehyde
• Methyl 2-bromobenzoate
• Bromobenzene
• Bromoxynil
• 3-(METHOXYMETHOXY)BENZALDEHYDE
• (Trifluoromethoxy)benzene
• 3-Bromofluorobenzene
• p-Anisaldehyde
• 2-(Trifluoromethoxy)aniline