SGK3 degrader-1
SGK3 degrader-1 Basic information
- Product Name:
- SGK3 degrader-1
- Synonyms:
-
- SGK3 degrader-1
- PROTAC SGK3 degrader-1
- SGK3-PROTAC1
- (2S,4R)-1-((S)-2-(tert-Butyl)-18-((R)-2-(((6-(4-((2-fluoro-5-methylphenyl)sulfonamido)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)methyl)morpholino)-4-oxo-6,9,12-trioxa-3-azaoctadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
- CAS:
- 2381320-35-8
- MF:
- C57H73FN10O11S2
- MW:
- 1157.38
- Mol File:
- 2381320-35-8.mol
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SGK3 degrader-1 Chemical Properties
- Density
- 1.309±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: ≥ 100 mg/mL (86.40 mM)
- form
- Solid
- pka
- 6.38±0.10(Predicted)
- color
- White to off-white
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SGK3 degrader-1 Usage And Synthesis
Uses
PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a von Hippel-Lindau ligand-based SKG3 PROTAC composed of a PEG3-C4-OBn (HY-130620) alkyl linker, an SGK3 degrader (red structure), and a VHL ligand (HY-150803, blue structure). PROTAC SGK3 degrader-1 (0.3 μM) induced 50% endogenous SGK3 degradation within 2 hours, and 80% SGK3 degradation was observed at 8 hours, accompanied by loss of phosphorylation of NDRG1 (SGK3 substrate)[1].
IC 50
SGK3
References
[1] Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. ACS Chem Biol. 2019 Sep 20;14(9):2024-2034. DOI:10.1021/acschembio.9b00505
SGK3 degrader-1Supplier
Nanjing Chemlin Chemical Co., Ltd
- Tel
- 025-83697070
- info@chemlin.com.cn
Sichuan Wei Keqi Biological Technology Co., Ltd.
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- 028-81700200 18116577057
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Shanghai YuanYe Biotechnology Co., Ltd.
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- 021-61312847; 18021002903
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Jilin Province Woda Biotechnology Co., Ltd.
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- 13504435624
- 1927928688@qq.com
TargetMol Chemicals Inc.
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- +1-781-999-5354; +17819995354
- marketing@targetmol.com