PROTAC Mcl1 degrader-1
PROTAC Mcl1 degrader-1 Basic information
- Product Name:
- PROTAC Mcl1 degrader-1
- Synonyms:
-
- PROTAC Mcl1 degrader-1
- Hexanediamide, N1-[2-[6-[(4-bromophenyl)thio]-1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl]ethyl]-N6-[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-
- N1-(2-(6-((4-Bromophenyl)thio)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl)-N6-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)adipamide
- N'-(2-{8-[(4-bromophenyl)sulfanyl]-2,4-dioxo-3-azatricyclo[7.3.1.0?,13]trideca-1(13),5,7,9,11-pentaen-3-yl}ethyl)-N-(6-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}hexyl)hexanediamide
- N1-[2-[6-[(4-Bromophenyl)thio]-1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl]ethyl]-N6-[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]hexanediamide
- CAS:
- 2163793-38-0
- MF:
- C45H45BrN6O8S
- MW:
- 909.84
- Mol File:
- 2163793-38-0.mol
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PROTAC Mcl1 degrader-1 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO: 50 mg/mL (54.95 mM)
- form
- Solid
- color
- Light yellow to yellow
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PROTAC Mcl1 degrader-1 Usage And Synthesis
Description
Mcl-1 Degrader C3 is a novel potent and selective degrader of Mcl-1.
Uses
PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC) based on Cereblon ligand, is a potently and selectively Mcl-1 (Bcl-2 family member) inhibitor with an IC50 of 0.78 μM. PROTAC Mcl1 degrader-1 inhibits Bcl-2 with an IC50 of 0.54 μM[1].
IC 50
Mcl-1: 0.78 μM (IC50); Bcl-2: 0.54 μM (IC50)
References
[1] Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Aug 21. DOI:10.1021/acs.jmedchem.9b00919
PROTAC Mcl1 degrader-1Supplier
Shanghai Chaolan Chemical Technology Center
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Jilin Province Woda Biotechnology Co., Ltd.
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TargetMol Chemicals Inc.
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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cjbscvictory
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