PROTAC Mcl1 degrader-1

Product Name: PROTAC Mcl1 degrader-1
CAS No.: 2163793-38-0
Chemical Name: PROTAC Mcl1 degrader-1
Synonyms: PROTAC Mcl1 degrader-1;N1-(2-(6-((4-Bromophenyl)thio)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl)-N6-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)adipamide;Hexanediamide, N1-[2-[6-[(4-bromophenyl)thio]-1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl]ethyl]-N6-[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-;N'-(2-{8-[(4-bromophenyl)sulfanyl]-2,4-dioxo-3-azatricyclo[7.3.1.0?,13]trideca-1(13),5,7,9,11-pentaen-3-yl}ethyl)-N-(6-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}hexyl)hexanediamide
CBNumber: CB05821217
Molecular Formula: C45H45BrN6O8S
Formula Weight: 909.84
MOL File: 2163793-38-0.mol

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PROTAC Mcl1 degrader-1 Property

storage temp.: Store at -20°C
solubility: DMSO: 50 mg/mL (54.95 mM)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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PROTAC Mcl1 degrader-1 Chemical Properties,Usage,Production

Description

Mcl-1 Degrader C3 is a novel potent and selective degrader of Mcl-1.

Uses

PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC) based on Cereblon ligand, is a potently and selectively Mcl-1 (Bcl-2 family member) inhibitor with an IC50 of 0.78 μM. PROTAC Mcl1 degrader-1 inhibits Bcl-2 with an IC50 of 0.54 μM[1].

IC 50

Mcl-1: 0.78 μM (IC₅₀); Bcl-2: 0.54 μM (IC₅₀)

References

[1] Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Aug 21. DOI:10.1021/acs.jmedchem.9b00919

PROTAC Mcl1 degrader-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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PROTAC Mcl1 degrader-1 Suppliers

China 14 United States 1 Global 15

Shanghai Chaolan Chemical Technology Center

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Jilin Province Woda Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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cjbscvictory

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Bide Pharmatech Ltd.

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TargetMol Chemicals Inc.

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Henan Alpha Chemical Co., Ltd.

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Nantong QuanYi Biotechnology Co., Ltd

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2163793-38-0, PROTAC Mcl1 degrader-1Related Search:

PROTAC MDM2 Degrader-4 PROTAC KRASG12C Degrader-LC-2 PROTAC RIPK degrader-2 PROTAC MDM2 Degrader-2 PROTAC PARP1 degrader PROTAC MDM2 Degrader-1 SGK3 degrader-1 Sirt2-PROTAC-1 PROTAC MDM2 Degrader-3

PROTAC Mcl1 degrader-1

Hexanediamide, N1-[2-[6-[(4-bromophenyl)thio]-1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl]ethyl]-N6-[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-

N1-(2-(6-((4-Bromophenyl)thio)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl)-N6-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)adipamide

N'-(2-{8-[(4-bromophenyl)sulfanyl]-2,4-dioxo-3-azatricyclo[7.3.1.0?,13]trideca-1(13),5,7,9,11-pentaen-3-yl}ethyl)-N-(6-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}hexyl)hexanediamide

2163793-38-0

C45H45BrN6O8S