PROTAC PARP1 degrader

Product Name: PROTAC PARP1 degrader
CAS No.: 2369022-68-2
Chemical Name: PROTAC PARP1 degrader
Synonyms: PROTAC PARP1 degrader;2-(4-(1-(1-(4-((4R,5S)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)-2-oxo-6,9,12,15-tetraoxa-3-azaheptadecan-17-yl)-1H-1,2,3-triazol-4-yl)phenyl)-2H-indazole-7-carboxamide;2-(4-{1-[14-(2-{4-[(4R,5S)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazole-1-carbonyl]-2-oxopiperazin-1-yl}acetamido)-3,6,9,12-tetraoxatetradecan-1-yl]-1H-1,2,3-triazol-4-yl}phenyl)-2H-indazole-7-carboxamide;2H-Indazole-7-carboxamide, 2-[4-[1-[17-[4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-oxo-1-piperazinyl]-16-oxo-3,6,9,12-tetraoxa-15-azaheptadec-1-yl]-1H-1,2,3-triazol-4-yl]phenyl]-
CBNumber: CB48054607
Molecular Formula: C58H63Cl2N11O10
Formula Weight: 1145.09
MOL File: 2369022-68-2.mol

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PROTAC PARP1 degrader Property

Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
form: Solid
pka: 14.32±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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PROTAC PARP1 degrader Chemical Properties,Usage,Production

Uses

PROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand. PROTAC PARP1 degrader induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader consists of E3 ubiquitinase ligand MDM2 ligand (HY-128836), blue part; target protein ligand PAPR1 ligand (HY-171543), red part; PROTAC linker N3-PEG4-C2-NH2 (HY-128834), black part[1][2].

Biological Activity

PROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand. It induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line with an IC50 of 6.12 μM.

IC 50

PARP1; MDM2

References

[1]. Zhao Q, et al. Induction of apoptosis in MDA-MB-231 breast cancer cells by a PARP1-targeting PROTAC small molecule. Chem Commun (Camb). 2019 Jan 2;55(3):369-372.

PROTAC PARP1 degrader Preparation Products And Raw materials

Raw materials

Preparation Products

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PROTAC PARP1 degrader Suppliers

China 9 United States 2 Global 11

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
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Jilin Province Woda Biotechnology Co., Ltd.

Tel: 13504435624
Email: 1927928688@qq.com
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
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Henan Alpha Chemical Co., Ltd.

Tel: 0371-55013243 15324716602
Email: 2853979810@qq.com
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ShenZhen Trendseen Biological Technology Co.,Ltd.

Tel: 13417589054;
Email: trendseenbio@gmail.com
Country: China
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Suzhou Zhongke New Drug Basket Biomedical Technology Co., Ltd.

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Email: shenlei@supharm.cn
Country: China
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Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
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Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd

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Shanghai Fine Biotech Co.，Ltd

Tel: 18221172427
Email: sale@fine-biotech.com
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2369022-68-2, PROTAC PARP1 degraderRelated Search:

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PROTAC PARP1 degrader

2H-Indazole-7-carboxamide, 2-[4-[1-[17-[4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-oxo-1-piperazinyl]-16-oxo-3,6,9,12-tetraoxa-15-azaheptadec-1-yl]-1H-1,2,3-triazol-4-yl]phenyl]-

2-(4-(1-(1-(4-((4R,5S)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)-2-oxo-6,9,12,15-tetraoxa-3-azaheptadecan-17-yl)-1H-1,2,3-triazol-4-yl)phenyl)-2H-indazole-7-carboxamide

2-(4-{1-[14-(2-{4-[(4R,5S)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazole-1-carbonyl]-2-oxopiperazin-1-yl}acetamido)-3,6,9,12-tetraoxatetradecan-1-yl]-1H-1,2,3-triazol-4-yl}phenyl)-2H-indazole-7-carboxamide

2369022-68-2