Sirt2-PROTAC-1

Product Name: Sirt2-PROTAC-1
CAS No.: 2098487-75-1
Chemical Name: Sirt2-PROTAC-1
Synonyms: Sirt2-PROTAC-1;PROTAC Sirt2 Degrader-1;N-{4-[4-({3-[(2-{2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamido}-1,3-thiazol-5-yl)methyl]phenoxy}methyl)-1H-1,2,3-triazol-1-yl]butyl}-2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide
CBNumber: CB24668512
Molecular Formula: C40H40N10O8S2
Formula Weight: 852.94
MOL File: 2098487-75-1.mol

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Sirt2-PROTAC-1 Property

Density: 1.52±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 100 mg/mL (117.24 mM);Water : < 0.1 mg/mL (insoluble)
form: Solid
pka: 7.94±0.50(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0028486
Product name: PROTACSirt2Degrader-1
Purity: 98.76%
Packaging: 5mg
Price: $900
Updated: 2021/12/16

ChemScene

Product number: CS-0028486
Product name: PROTACSirt2Degrader-1
Purity: 98.76%
Packaging: 10mg
Price: $1500
Updated: 2021/12/16

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Sirt2-PROTAC-1 Chemical Properties,Usage,Production

Uses

PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s>100 μM)[1].

IC 50

SIRT2: 0.25 μM (IC₅₀)

References

[1] Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491. DOI:10.1021/acs.jmedchem.6b01872

Sirt2-PROTAC-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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Sirt2-PROTAC-1 Suppliers

China 21 United States 3 Global 24

Beijing Jin Ming Biotechnology Co., Ltd.

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2098487-75-1, Sirt2-PROTAC-1Related Search:

PROTAC MDM2 Degrader-4 PROTAC KRASG12C Degrader-LC-2 PROTAC RIPK degrader-2 PROTAC MDM2 Degrader-2 PROTAC PARP1 degrader PROTAC MDM2 Degrader-1 SGK3 degrader-1 PROTAC MDM2 Degrader-3 PROTAC Mcl1 degrader-1

Sirt2-PROTAC-1

PROTAC Sirt2 Degrader-1

N-{4-[4-({3-[(2-{2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamido}-1,3-thiazol-5-yl)methyl]phenoxy}methyl)-1H-1,2,3-triazol-1-yl]butyl}-2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide

2098487-75-1

C40H40N10O8S2