PROTAC RIPK degrader-2

Product Name: PROTAC RIPK degrader-2
CAS No.: 1801547-16-9
Chemical Name: PROTAC RIPK degrader-2
Synonyms: PROTAC_RIPK2;PROTAC RIPK degrader-2;PROTACRIPKdegrader-2/PROTAC_RIPK2;(2S,4R)-1-[(2S)-2-[14-({4-[(1,3-benzothiazol-5-yl)amino]-6-(2-methylpropane-2-sulfonyl)quinolin-7-yl}oxy)-3,6,9,12-tetraoxatetradecanamido]-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide;PROTAC_RIPK2 2-(2-(2-(2-((4-(benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinolin-7-yl)oxy)ethoxy)ethoxy)ethoxy)ethyl ((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate
CBNumber: CB65821239
Molecular Formula: C52H65N7O11S3
Formula Weight: 1060.31
MOL File: 1801547-16-9.mol

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PROTAC RIPK degrader-2 Property

Boiling point:: 1196.5±65.0 °C(Predicted)
Density: 1.315±0.06 g/cm3(Predicted)
pka: 13.54±0.46(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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PROTAC RIPK degrader-2 Chemical Properties,Usage,Production

Uses

PROTAC RIPK degraders -2 is a non-peptide PROTAC based on von Hippel-Lindau and targets serine-threonine kinase RIPK2, which is highly selective to the degradation of RIPK2. PROTAC RIPK degrader-2 acts as an activator to increase cell death and activate ion channels in cancer cells. PROTAC RIPK degrader-2 also can inhibit protein interactions, such as receptors and ligands, involved in a variety of diseases, such as cancer and diabetes[1][2].

IC 50

RIPK2; VHL

References

[1] Bondeson DP, et al. Catalytic in vivo protein knockdown by small-molecule PROTACs. Nat Chem Biol. 2015 Aug;11(8):611-7. DOI:10.1038/nchembio.1858
[2] Wang C, et al. VHL-based PROTACs as potential therapeutic agents: Recent progress and perspectives. Eur J Med Chem. 2022 Jan 5;227:113906. DOI:10.1016/j.ejmech.2021.113906

PROTAC RIPK degrader-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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PROTAC RIPK degrader-2 Suppliers

China 17 United States 2 Global 19

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
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Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
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Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
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Jilin Province Woda Biotechnology Co., Ltd.

Tel: 13504435624
Email: 1927928688@qq.com
Country: China
ProdList: 1615
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
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ShangHai ChuanQian Chemcial Technique Centre

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Henan Alpha Chemical Co., Ltd.

Tel: 0371-55013243 15324716602
Email: 2853979810@qq.com
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Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd

Tel: 024-024-024-88590548 18341751992
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ShenZhen Trendseen Biological Technology Co.,Ltd.

Tel: 13417589054;
Email: trendseenbio@gmail.com
Country: China
ProdList: 9069
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1801547-16-9, PROTAC RIPK degrader-2Related Search:

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PROTAC RIPK degrader-2

PROTAC_RIPK2

PROTAC_RIPK2 2-(2-(2-(2-((4-(benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinolin-7-yl)oxy)ethoxy)ethoxy)ethoxy)ethyl ((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

PROTACRIPKdegrader-2/PROTAC_RIPK2

(2S,4R)-1-[(2S)-2-[14-({4-[(1,3-benzothiazol-5-yl)amino]-6-(2-methylpropane-2-sulfonyl)quinolin-7-yl}oxy)-3,6,9,12-tetraoxatetradecanamido]-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide

1801547-16-9

C52H65N7O11S3