PROTAC MDM2 Degrader-1

Product Name: PROTAC MDM2 Degrader-1
CAS No.: 2249944-98-5
Chemical Name: PROTAC MDM2 Degrader-1
Synonyms: PROTAC MDM2 Degrader-1;1-Piperazineacetamide, N,N'-[oxybis(2,1-ethanediyloxy-3,1-propanediyl)]bis[4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-oxo-, rel-
CBNumber: CB45821235
Molecular Formula: C74H84Cl4N10O13
Formula Weight: 1463.33
MOL File: 2249944-98-5.mol

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PROTAC MDM2 Degrader-1 Property

Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 14.46±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0100638
Product name: PROTACMDM2Degrader-1
Purity: 98.39%
Packaging: 10mg
Price: $1800
Updated: 2021/12/16

ChemScene

Product number: CS-0100638
Product name: PROTACMDM2Degrader-1
Purity: 98.39%
Packaging: 25mg
Price: $3300
Updated: 2021/12/16

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PROTAC MDM2 Degrader-1 Chemical Properties,Usage,Production

Uses

PROTAC MDM2 Degrader-1 (Compound 15a) is a MDM2 PROTAC degrader. The structures of both Linker ends of PROTAC MDM2 Degrader-1 are MDM2 ligands. PROTAC MDM2 Degrader-1 can not only block the binding of p53-MDM2, but also degrade the target MDM2 protein by utilizing the function of the E3 ligase of MDM2 itself, thus exerting an anti-tumor effect. (Pink: MDM2 ligand 2 (HY-128836); Black: Linker (HY-128844); Blue: E3 ligase Ligand 15 (HY-128836))[1]

IC 50

MDM2

References

[1] Method of inducing of self-degradation of MDM2 using E3 ubiquitin ligase dimer amide small molecule PROTACs. CN108610333A.

PROTAC MDM2 Degrader-1 Preparation Products And Raw materials

Raw materials

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PROTAC MDM2 Degrader-1 Suppliers

China 8 United States 1 Global 9

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
Advantage: 56

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Jilin Province Woda Biotechnology Co., Ltd.

Tel: 13504435624
Email: 1927928688@qq.com
Country: China
ProdList: 1615
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
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ShenZhen Trendseen Biological Technology Co.,Ltd.

Tel: 13417589054;
Email: trendseenbio@gmail.com
Country: China
ProdList: 9069
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9835
Advantage: 58

Adooq Bioscience LLC

Tel: 400-025-6535
Email: sales@adooq.cn
Country: China
ProdList: 6215
Advantage: 58

Guangzhou Jingyan Biotechnology Co., Ltd.

Tel: 13822277471
Country: CHINA
ProdList: 187
Advantage: 58

2249944-98-5, PROTAC MDM2 Degrader-1Related Search:

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PROTAC MDM2 Degrader-1

1-Piperazineacetamide, N,N'-[oxybis(2,1-ethanediyloxy-3,1-propanediyl)]bis[4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-oxo-, rel-

2249944-98-5

C74H84Cl4N10O13