PROTAC CRBN Degrader-1

Product Name: PROTAC CRBN Degrader-1
CAS No.: 2358775-70-7
Chemical Name: PROTAC CRBN Degrader-1
Synonyms: CRBN PROTAC?14a;PROTAC CRBN Degrader-1;N1-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-N20-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,9,12,18-tetraoxaicosane-1,20-diamide;N'-(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethyl)-N-[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]-3,9,12,18-tetraoxaicosanediamide
CBNumber: CB88054807
Molecular Formula: C53H72N8O13S
Formula Weight: 1061.25
MOL File: Mol file

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PROTAC CRBN Degrader-1 Property

Boiling point:: 1241.2±65.0 °C(Predicted)
Density: 1.294±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 200 mg/mL (188.46 mM)
form: Solid
pka: 10.74±0.40(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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PROTAC CRBN Degrader-1 Chemical Properties,Usage,Production

Description

CRBN PROTAC? 14a is a cereblon degrader. It comprises a ligand for Von Hippel Lindau (VHL) protein joined by a linker to a cereblon targeting ligand. It preferentially degrades cereblon, and induces rapid and profound cereblon degradation.

storage

Store at -20°C

PROTAC CRBN Degrader-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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PROTAC CRBN Degrader-1 Suppliers

China 10 United States 2 Global 12

Sichuan Wei Keqi Biological Technology Co., Ltd.

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TargetMol Chemicals Inc.

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PROTAC CRBN Degrader-1

CRBN PROTAC?14a

N1-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-N20-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,9,12,18-tetraoxaicosane-1,20-diamide

N'-(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethyl)-N-[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]-3,9,12,18-tetraoxaicosanediamide

2358775-70-7