PROTAC BRD4 Degrader-5
- Product Name
- PROTAC BRD4 Degrader-5
- CAS No.
- 2409538-70-9
- Chemical Name
- PROTAC BRD4 Degrader-5
- Synonyms
- PROTAC BRD4 Degrader-5;(2S,4R)-1-[(2S)-2-(2-{2-[2-(2-{2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.02,?]trideca-2(6),4,7,10,12-pentaen-9-yl]acetamido}ethoxy)ethoxy]ethoxy}acetamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
- CBNumber
- CB27243570
- Molecular Formula
- C50H62ClN9O8S2
- Formula Weight
- 1016.67
- MOL File
- Mol file
PROTAC BRD4 Degrader-5 Property
- Density
- 1.38±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 145 mg/mL (142.62 mM)
- pka
- 13.54±0.46(Predicted)
- form
- Solid
- color
- White to off-white
- Water Solubility
- Water: < 0.1 mg/mL (insoluble)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0130208
- Product name
- PROTACBRD4Degrader-5
- Purity
- 99.51%
- Packaging
- 10mg
- Price
- $2200
- Updated
- 2021/12/16
PROTAC BRD4 Degrader-5 Chemical Properties,Usage,Production
Uses
PROTAC BRD4 Degrader-5 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1].
IC 50
BRD4
References
[1] Mar A Maneiro, et al. Antibody-PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4. ACS Chem Biol. 2020 Jun 19;15(6):1306-1312. DOI:10.1021/acschembio.0c00285
PROTAC BRD4 Degrader-5 Preparation Products And Raw materials
Raw materials
Preparation Products
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