PROTAC FKBP Degrader-3

Product Name: PROTAC FKBP Degrader-3
CAS No.: 2079056-43-0
Chemical Name: PROTAC FKBP Degrader-3
Synonyms: PROTAC FKBP Degrader-3;(1R)-3-(3,4-dimethoxyphenyl)-1-(3-{[(2-{2-[2-({[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}methoxy)ethoxy]ethoxy}ethyl)carbamoyl]methoxy}phenyl)propyl (2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carboxylate
CBNumber: CB28054810
Molecular Formula: C68H90N6O17S
Formula Weight: 1295.54
MOL File: 2079056-43-0.mol

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PROTAC FKBP Degrader-3 Property

Boiling point:: 1297.9±65.0 °C(Predicted)
Density: 1.233±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 25 mg/mL (19.30 mM)
form: Solid
pka: 13.54±0.46(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0111726
Product name: PROTACFKBPDegrader-3
Purity: 98.73%
Packaging: 1mg
Price: $680
Updated: 2021/12/16

ChemScene

Product number: CS-0111726
Product name: PROTACFKBPDegrader-3
Purity: 98.73%
Packaging: 5mg
Price: $1350
Updated: 2021/12/16

ChemScene

Product number: CS-0111726
Product name: PROTACFKBPDegrader-3
Purity: 98.73%
Packaging: 10mg
Price: $2150
Updated: 2021/12/16

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PROTAC FKBP Degrader-3 Chemical Properties,Usage,Production

Uses

PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an von Hippel-Lindau binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrader[1].

IC 50

VHL; FKBP

References

[1] Ottis P, et al. Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation. ACS Chem Biol. 2017 Oct 20;12(10):2570-2578. DOI:10.1021/acschembio.7b00485

PROTAC FKBP Degrader-3 Preparation Products And Raw materials

Raw materials

Preparation Products

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PROTAC FKBP Degrader-3 Suppliers

China 10 United States 2 Global 12

Sichuan Wei Keqi Biological Technology Co., Ltd.

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TargetMol Chemicals Inc.

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TargetMol Chemicals Inc.

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Nantong QuanYi Biotechnology Co., Ltd

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RD International Technology Co., Limited

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PROTAC FKBP Degrader-3

(1R)-3-(3,4-dimethoxyphenyl)-1-(3-{[(2-{2-[2-({[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}methoxy)ethoxy]ethoxy}ethyl)carbamoyl]methoxy}phenyl)propyl (2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carboxylate

2079056-43-0