PROTAC MDM2 Degrader-1
PROTAC MDM2 Degrader-1 Basic information
- Product Name:
- PROTAC MDM2 Degrader-1
- Synonyms:
-
- PROTAC MDM2 Degrader-1
- 1-Piperazineacetamide, N,N'-[oxybis(2,1-ethanediyloxy-3,1-propanediyl)]bis[4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-oxo-, rel-
- CAS:
- 2249944-98-5
- MF:
- C74H84Cl4N10O13
- MW:
- 1463.33
- Mol File:
- 2249944-98-5.mol
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PROTAC MDM2 Degrader-1 Chemical Properties
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 14.46±0.46(Predicted)
- color
- White to off-white
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PROTAC MDM2 Degrader-1 Usage And Synthesis
Uses
PROTAC MDM2 Degrader-1 (Compound 15a) is a MDM2 PROTAC degrader. The structures of both Linker ends of PROTAC MDM2 Degrader-1 are MDM2 ligands. PROTAC MDM2 Degrader-1 can not only block the binding of p53-MDM2, but also degrade the target MDM2 protein by utilizing the function of the E3 ligase of MDM2 itself, thus exerting an anti-tumor effect. (Pink: MDM2 ligand 2 (HY-128836); Black: Linker (HY-128844); Blue: E3 ligase Ligand 15 (HY-128836))[1]
IC 50
MDM2
References
[1] Method of inducing of self-degradation of MDM2 using E3 ubiquitin ligase dimer amide small molecule PROTACs. CN108610333A.
PROTAC MDM2 Degrader-1Supplier
Sichuan Wei Keqi Biological Technology Co., Ltd.
- Tel
- 028-81700200 18116577057
- 3003855609@qq.com
Fan De(Beijing) Biotechnology Co., Ltd.
- Tel
- 15911056312
- liming@bio-fount.com
Jilin Province Woda Biotechnology Co., Ltd.
- Tel
- 13504435624
- 1927928688@qq.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
- Tel
- 18818260767
- sales@chemegen.com