HEXOBARBITAL Chemical Properties

Melting point:

145-147°

Boiling point:

378.73°C (rough estimate)

Density 

1.1623 (rough estimate)

refractive index 

1.5460 (estimate)

Flash point:

11 °C

storage temp. 

2-8°C

pka

7.99±0.10(Predicted)

Water Solubility 

434.7mg/L(25 ºC)

EPA Substance Registry System

Hexobarbital (56-29-1)

Safety Information

Hazard Codes 

Xn,T,F

Risk Statements 

22-39/23/24/25-23/24/25-11

Safety Statements 

36/37/39-45-36/37-16-7

RIDADR 

3249

WGK Germany 

3

RTECS 

CQ2625000

HazardClass 

6.1(b)

PackingGroup 

III

MSDS

• Language:English Provider:SigmaAldrich

HEXOBARBITAL Usage And Synthesis

Description

Hexobarbital, 5-(cyclohexen-1- yl)-1,5-dimethylbarbituric acid,Mr 236.26. The acid forms colorless crystals that turn pink on exposure to light, mp 146 ?C. A 10 % aqueous solution of the sodium salt, Mr 258.25, has a pH of 11.5.

Chemical Properties

White crystals.

Uses

Medicine (sedative).

Definition

ChEBI: A member of the class of barbiturates taht is barbituric acid substituted at N-1 by methyl and at C-5 by methyl and cyclohex-1-enyl groups.

brand name

Cyclonal sodium;Cyclopan;Dorico soluble;Eviderm;Evipal sodium;Evipanl;Hexanal;Hexanastab oral.

World Health Organization (WHO)

Hexobarbital is a short-acting barbiturate. See WHO comment for barbiturates.

Clinical Use

Methohexital sodium is a short-acting anesthetic administered intravenously. It is very potent and has the shortest duration of action among the barbiturates used. A disturbing factor is that rather frequently it causes hiccups directly after injection. Patients are reported to recover rapidly from anesthesia. Abuse can lead to addiction.

Synthesis

Hexobarbital sodium is prepared by condensation of methyl(cyclohexen-1-yl)cyanoacetic ester with dicyanodiamide to 5-(cyclohexen- 1-yl)-5-methyl-2,6-diimino-3-cyanobarbituric acid, followed by methylation with dimethyl sulfate and hydrolysis with 25 % sulfuric acid .

HEXOBARBITAL(56-29-1)Related Product Information

• DIHYDROTHYMINE
• 2-(1-CYCLOHEXENYL)ETHYLAMINE
• HEXOBARBITAL
• N,N,2,2-TETRAMETHYL-1,3-PROPANEDIAMINE
• N,N,2-TRIMETHYLPROPIONAMIDE
• 2,2,5-Trimethyl-4-hexenal dimethyl acetal
• CYCLOBARBITAL
• 2-ETHYL-2-HEXENAL,TRANS-2-ETHYL-2-HEXENAL
• TRANS-2-ETHYL-2-HEXENAL,2-ETHYL-2-HEXENAL
• 3-HEXENAL
• 2-PHENYL-5-METHYL-2-HEXENAL,5-METHYL-2-PHENYL-2-HEXENAL
• TRANS-2-HEXENAL,T2 HEXENAL
• 2-HEXENAL DIETHYL ACETAL,T2 HEXENAL DIETHYL ACETAL,TRANS-2-HEXENAL DIETHYL ACETAL
• trans-2-Hexenal propyleneglycol acetal
• 2-ISOPROPYL-5-METHYL-2-HEXENAL
• CIS-3-HEXENAL
• 2,2,5-Trimethyl-4-hexenal
• CIS-3-HEXENAL ACETAL