Ethyl methyldopate hydrochloride Chemical Properties

storage temp. 

2-8°C

form 

crystalline powder

Major Application

pharmaceutical
pharmaceutical small molecule

InChI

1S/C12H17NO4.ClH/c1-3-17-11(16)12(2,13)7-8-4-5-9(14)10(15)6-8;/h4-6,14-15H,3,7,13H2,1-2H3;1H/t12-;/m0./s1

InChIKey

QSRVZCCJDKYRRF-YDALLXLXSA-N

SMILES

[Cl-].N[C@](Cc1cc(c(cc1)O)O)(C)C(=O)OCC.[H+]

Safety Information

WGK Germany 

WGK 3

HS Code 

2922504500

Storage Class

11 - Combustible Solids

Ethyl methyldopate hydrochloride Usage And Synthesis

Uses

Ethyl methyldopate hydrochloride is Antihypertensive.

brand name

Aldomet (Merck).

General Description

Methyldopatehydrochloride, L-3-(3,4-dihydroxyphenyl)-2-methylalanineethyl ester hydrochloride (Aldomet ester hydrochloride), α-methyldopa, lowers blood pressure by inhibitingthe outflow of sympathetic vasoconstrictor impulses fromthe brain. Early studies had suggested that the hypotensiveaction of α-methyldopa was a result of the peripheral propertiesof the drug as a decarboxylase inhibitor or a falsetransmitter.

Clinical Use

Ethyl methyldopate hydrochloride is used as a step 2 agent and is recommendedfor patients with high blood pressure who are not responsiveto diuretic therapy alone. Ethyl methyldopate hydrochloride, suitable for oral use,is a zwitterion and is not soluble enough for parenteral use.The problem was solved by making the ester, leaving theamine free to form the water-soluble hydrochloride salt. It issupplied as a stable, buffered solution, protected with antioxidantsand chelating agents.

in vivo

IC 50

α adrenergic receptor

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