Ethyl methyldopate hydrochloride
Ethyl methyldopate hydrochloride Basic information
- Product Name:
- Ethyl methyldopate hydrochloride
- Synonyms:
-
- methyldopa ethyl hydrochloride
- METHYLDOPAETHYLHCL
- (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methyl-propionic acid ethyl ester hydrochloride
- METHYLDOPATE HCL
- METHYLDOPATE HYDROCHLORIDE
- ethyl methyldopate hydrochloride
- Levo-3-(3,4-dihydroxyphenyl)-2-methylalanine ethyl ester hydrochloride
- ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoate hydrochloride
- CAS:
- 2508-79-4
- MF:
- C12H18ClNO4
- MW:
- 275.73
- EINECS:
- 219-720-3
- Product Categories:
-
- Pharmaceutical Intermediates
- Mol File:
- 2508-79-4.mol
Ethyl methyldopate hydrochloride Usage And Synthesis
Uses
Ethyl methyldopate hydrochloride is Antihypertensive.
brand name
Aldomet (Merck).
General Description
Methyldopatehydrochloride, L-3-(3,4-dihydroxyphenyl)-2-methylalanineethyl ester hydrochloride (Aldomet ester hydrochloride), α-methyldopa, lowers blood pressure by inhibitingthe outflow of sympathetic vasoconstrictor impulses fromthe brain. Early studies had suggested that the hypotensiveaction of α-methyldopa was a result of the peripheral propertiesof the drug as a decarboxylase inhibitor or a falsetransmitter.
Clinical Use
Ethyl methyldopate hydrochloride is used as a step 2 agent and is recommendedfor patients with high blood pressure who are not responsiveto diuretic therapy alone. Ethyl methyldopate hydrochloride, suitable for oral use,is a zwitterion and is not soluble enough for parenteral use.The problem was solved by making the ester, leaving theamine free to form the water-soluble hydrochloride salt. It issupplied as a stable, buffered solution, protected with antioxidantsand chelating agents.
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Ethyl methyldopate hydrochloride(2508-79-4)Related Product Information
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- Ethyl acetoacetate
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- Tris(trimethylsilyl)phosphate
- Ethyl acrylate
- Ethylparaben
- Ethyl cellulose
- Glycine ethyl ester hydrochloride
- Tetraethyl orthosilicate
- Ethylbenzene
- Ethanol
- DL-ALPHA-METHYLTYROSINE
- 2-METHYL-3-(3,4-DIHYDROXYPHENYL)-DL-ALANINE
- ALPHA-METHYL-L-P-TYROSINE
- 2-Amino-2-methyl-propionic acid ethyl ester hydrochloride
- L-TYROSINE ETHYL ESTER HYDROCHLORIDE
- Diethyl ether