DIBUTYLCARBAMYL CHLORIDE
DIBUTYLCARBAMYL CHLORIDE Basic information
- Product Name:
- DIBUTYLCARBAMYL CHLORIDE
- Synonyms:
-
- DIBUTYLCARBAMYL CHLORIDE
- 1,6-dibutyl-carbamicchlorid
- dibutyl-carbamoylchlorid
- dibutylcarbamoylchloride
- tl459
- N,N-dibutylcarbamoyl chloride
- Dibutylcarbamic acid chloride
- Brn 2040828
- CAS:
- 13358-73-1
- MF:
- C9H18ClNO
- MW:
- 191.7
- EINECS:
- 236-410-3
- Product Categories:
-
- Acid Halides
- Carbonyl Compounds
- Organic Building Blocks
- Mol File:
- 13358-73-1.mol
DIBUTYLCARBAMYL CHLORIDE Chemical Properties
- Boiling point:
- 257-260 °C(lit.)
- Density
- 0.985 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.456(lit.)
- Flash point:
- 110 °C
- pka
- -1.85±0.70(Predicted)
Safety Information
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 3265 8/PG 3
- WGK Germany
- 3
- RTECS
- FD2230000
- HazardClass
- IRRITANT
MSDS
- Language:English Provider:SigmaAldrich
DIBUTYLCARBAMYL CHLORIDE Usage And Synthesis
Uses
It is reported that Dibutylcarbamoyl Chloride is used as a reagent for the preparation of 7-azaindole-1,3-dicarboxamide hydroxyethylamine which exhibited potent BACE-1 enzyme inhibition. Also it is used for the preparation of copper salicylaldehyde semicarbazone complex which showed cytotoxicity in human cancer cells.
Preparation
In a 100 mL roundbottomed flask were placed dibutylamine (6.45 g, 0.05 mol), pyridine (4.0 g, 0.05 mol), N-cyclohexyl-N0,N0,N00,N00-tetraethylguanidine (12.7 g, 0.05 mol), and toluene (40 mL). The resulting solution was cooled to 10 °C using an ice/salt bath and carbon dioxide was bubbled into the cooled solution for 30 min. After this period of time, the pre-formed carbamate solution was added in a single portion via a cannula to a cooled ( 10 °C) solution of thionyl chloride (6 g, 0.05 mol) in toluene (40 mL). The reaction mixture was stirred at 10 °C for 45 min. It was then poured into 0.1 m aq. HCl (100 mL), giving rise to two layers. The organic layer was separated, dried over anhydrous Mg2SO4, filtered, and the solvent was removed in vacuo. The residue was distilled in vacuo (1 mmHg) at 95–98 °C to give 7.62 g (79%) of N,N-dibutyl carbamoyl chloride.
DIBUTYLCARBAMYL CHLORIDESupplier
- Tel
- 021-61259108 18621169109
- market03@meryer.com
- Tel
- 021-021-58432009 400-005-6266
- sales8178@energy-chemical.com
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Tel
- 0571-82693216
- info@yuhaochemical.com
- Tel
- 4008-755-333 18080918076
- 800078821@qq.com