N,N-Dibutylformamide Chemical Properties

Melting point:

<-30°C

Boiling point:

120 °C15 mm Hg(lit.)

Density 

0.864 g/mL at 25 °C(lit.)

vapor pressure 

<1 mm Hg ( 20 °C)

refractive index 

n20/D 1.44(lit.)

Flash point:

213 °F

storage temp. 

2-8°C

form 

clear liquid

pka

-0.44±0.70(Predicted)

Specific Gravity

0.864

color 

Colorless to Light yellow

Water Solubility 

Insoluble in water.

BRN 

636100

InChI

1S/C9H19NO/c1-3-5-7-10(9-11)8-6-4-2/h9H,3-8H2,1-2H3

InChIKey

NZMAJUHVSZBJHL-UHFFFAOYSA-N

SMILES

[H]C(=O)N(CCCC)CCCC

LogP

2 at 23℃

CAS DataBase Reference

761-65-9(CAS DataBase Reference)

NIST Chemistry Reference

Formamide, N,N-dibutyl-(761-65-9)

EPA Substance Registry System

N,N-Dibutylformamide (761-65-9)

Safety Information

Hazard Codes 

Xi

Risk Statements 

37-43-36/37/38

Safety Statements 

36/37-37/39-26

WGK Germany 

1

RTECS 

LQ1833000

TSCA 

TSCA listed

HS Code 

29241990

Storage Class

10 - Combustible liquids

Hazard Classifications

Skin Sens. 1

MSDS

• Language:English Provider:N,N-Dibutylformamide
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

N,N-Dibutylformamide Usage And Synthesis

Chemical Properties

CLEAR COLOURLESS TO YELLOW LIQUID

Uses

N,N-dibutylformamide is a pollutant sourcing from aerosols and or exhaust gases in Los Angeles.

Flammability and Explosibility

Not classified

Safety Profile

Poison by intraperitoneal route. An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx.

Synthesis

In a glove box, catalyst Rh/I (16.5 mg), N-methylpyrrolidone (1.0 mL), di-n-butylamine (168 ??L, 1 mmol), and decane (10 ??L,0.05 mmol) were added to the reaction kettle. Then CO2 was charged to replace the nitrogen in the kettle for three times, and then CO2 (20 atm) and H2 (20 atm) were charged, and the reaction was stirred in an oil bath at 100 ?? for 24 h. After the reaction was completed, the kettle was cooled down to room temperature with an ice-water bath, and then the gas phase was measured after centrifugation of the supernatant, and the yield was 68%.

Purification Methods

Purify the amide by fractional distillation [Mandel & Hill J Am Chem Soc 76 3981 1954]. [Beilstein 4 IV 565.]

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