Naxitamab
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Naxitamab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
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Naxitamab Usage And Synthesis
Uses
Naxitamab (Hu3F8) is a humanized monoclonal antibody targeting the disialoganglioside GD2. Naxitamab can be used in research of neuroblastoma, osteosarcoma and other GD2-positive cancers[1].
in vivo
Naxitamab (Hu3F8; 100 mg/kg; i.v.; twice a week, for 4 weeks; athymic nude mice with LAN-1 xenografts) inhibits tumor growth in neuroblastoma xenografts[1].
| Animal Model: | Female athymic nude mice with LAN-1 xenografts[1] |
| Dosage: | 100 mg/kg |
| Administration: | Intravenous injection; twice a week, for 4 weeks |
| Result: | Inhibited tumor growth and prolonged the survival time. |
References
[1] Cheung NK, et, al. Humanizing murine IgG3 anti-GD2 antibody m3F8 substantially improves antibody-dependent cell-mediated cytotoxicity while retaining targeting in vivo. Oncoimmunology. 2012 Jul 1;1(4):477-486. DOI:10.4161/onci.19864
[2] Markham A. Naxitamab: First Approval. Drugs. 2021 Feb;81(2):291-296. DOI:10.1007/s40265-021-01467-4
NaxitamabSupplier
Shanghai YuanYe Biotechnology Co., Ltd.
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TargetMol Chemicals Inc.
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Guangzhou Hongyuan Chemical Co.,Ltd
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Wuhan Chemstan Biotechnology Co., Ltd.
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TargetMol Chemicals Inc.
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