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Dibemethine

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Dibemethine Basic information

Product Name:
Dibemethine
Synonyms:
  • METHYL DIBENZYLAMINE
  • DIBENZYL METHYL AMINE
  • DIBEMETHINE
  • N-Methyl Di-Benzylamine
  • N-methyl-N-(phenylmethyl) -Benzenemethanamine
  • n-methyl-n-(phenylmethyl)-benzenemethanamin
  • N,N-Dibenzyl-N-methylamine
  • L 566
CAS:
102-05-6
MF:
C15H17N
MW:
211.3
EINECS:
203-001-6
Mol File:
102-05-6.mol
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Dibemethine Chemical Properties

Melting point:
50 °C
Boiling point:
304-305 °C(Press: 765.5 Torr)
Density 
0.996 g/cm3(Temp: 22 °C)
storage temp. 
Sealed in dry,Room Temperature
pka
7.85±0.50(Predicted)
EPA Substance Registry System
Benzenemethanamine, N-methyl-N-(phenylmethyl)- (102-05-6)
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Dibemethine Usage And Synthesis

Uses

Dibemethine is active against chloroquinone-resistant Plasmodium falciparum and inhibit chloroquine transport via the P. falciparum chloroquine-resistance transporter (PfCRT).

Synthesis Reference(s)

Journal of the American Chemical Society, 95, p. 3038, 1973 DOI: 10.1021/ja00790a064
Tetrahedron Letters, 20, p. 3395, 1979 DOI: 10.1016/S0040-4039(01)95418-8

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