Geldanamycin-FITC Chemical Properties

storage temp. 

-20°C (des.)

solubility 

Soluble in DMSO (greater than 10 mg/ml)

form 

solid

color 

Purple

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Geldanamycin-FITC Usage And Synthesis

Description

Geldanamycin-FITC is a novel geldanamycin fluorescent probe1?that may be used in a fluorescence polarization assay for HSP-90 inhibitors.2,3?May also be used for detection of cell surface HSP-90 and for other applications. Fluorescent geldanamycin probes have been used to characterize geldanamycin drug-target interactions for effective translation of?in vitro?pharmacology to cellular and?in vivo?efficacy.4

Uses

Geldanamycin-FITC is a novel geldanamycin fluorescent probe. Fluorescent geldanamycin probes have been used to characterize geldanamycin drug-target interactions for effective translation of in vitro pharmacology to cellular and in vivo efficacy.

IC 50

HSP90

References

[1] LAURA LLAUGER-BUFI . Synthesis of novel fluorescent probes for the molecular chaperone Hsp90[J]. Bioorganic & Medicinal Chemistry Letters, 2003, 13 22: Pages 3975-3978. DOI:10.1016/j.bmcl.2003.08.065
[2] JOUNGNAM KIM . Development of a Fluorescence Polarization Assay for the Molecular Chaperone Hsp90[J]. SLAS Discovery, 2004, 9 5: Pages 375-381. DOI:10.1177/1087057104265995
[3] CAROL AUSTIN . Fragment Screening Using Capillary Electrophoresis (CEfrag) for Hit Identification of Heat Shock Protein 90 ATPase Inhibitors[J]. SLAS Discovery, 2012, 17 7: Pages 868-876. DOI:10.1177/1087057112445785
[4] LATA T GOOLJARSINGH. A biochemical rationale for the anticancer effects of Hsp90 inhibitors: slow, tight binding inhibition by geldanamycin and its analogues.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2006: 7625-7630. DOI:10.1073/pnas.0602650103

Geldanamycin-FITC(2969156-01-0)Related Product Information

• TYRPHOSTIN AG 1296
• Vorinostat
• (+)-Camptothecin
• Sunitinib Malate