piperylone
piperylone Basic information
- Product Name:
- piperylone
- Synonyms:
-
- piperylone
- Piperylonum
- 4-Ethyl-1,2-dihydro-2-(1-methylpiperidin-4-yl)-5-phenyl-3H-pyrazol-3-one
- 4-ethyl-2-(1-methyl-4-piperidyl)-5-phenyl-1H-pyrazol-3-one
- 4-ethyl-2-(1-methylpiperidin-4-yl)-5-phenyl-1H-pyrazol-3-one
- PR66
- 3H-Pyrazol-3-one, 4-ethyl-1,2-dihydro-2-(1-methyl-4-piperidinyl)-5-phenyl-
- CAS:
- 2531-04-6
- MF:
- C17H23N3O
- MW:
- 285.38
- EINECS:
- 2197884
- Mol File:
- 2531-04-6.mol
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piperylone Chemical Properties
- Boiling point:
- 413.0±55.0 °C(Predicted)
- Density
- 1.121±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- pK1 5.90; pK2 9.15(at 25℃)
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piperylone Usage And Synthesis
Originator
Palerol, Novartis
Manufacturing Process
A mixture of 8.8 parts of α-ethylbenzoylacetic acid ethyl ester and 5,3 parts of N-methyl-piperidyl-4-hydrazine is allowed to stand for 30 min at 22°C, after which the mixture is heated for 5 hours to 130°C under a pressure of 12 mm. After 4 hours 1-(N-methylpiperidyl-4)-3-phenyl-4-ethylpyrazolone-5 begins crystallize out. The reaction mixture is allowed to cool, after which the crystal mass is triturated with ether and then recrystallized from methanol-ether or from acetone. Melting point 159-161°C.
Therapeutic Function
Analgesic
piperyloneSupplier
MedChemexpress LLC
- Tel
- 021-58955995
- sales@medchemexpress.cn
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
Beijing Jin Ming Biotechnology Co., Ltd.
- Tel
- 010-60605840
- psaitong@jm-bio.com
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd
- Tel
- 17691182729 18161915376
- 1046@dideu.com