[LEU27]-MELAN-A Chemical Properties

Boiling point:

1353.421±65.00 °C(Press: 760.00 Torr)(predicted)

Density 

1.201±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

pka

3.322±0.10(predicted)

Sequence

Glu-Leu-Ala-Gly-Ile-Gly-Ile-Leu-Thr-Val

[LEU27]-MELAN-A Usage And Synthesis

Uses

Melan-A/MART-1 analog ([Leu27]-Melan-A, MART-1 (26-35)) is a biological active peptide. (This Melan-A (26-35) analog, Leu substituted for Ala at position 27, shows better HLA-A*0201 binding properties as well as better immunogenicity and antigenicity than the natural Melan-A (26-35).Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

[LEU27]-MELAN-A(204060-45-7)Related Product Information

• MART-1 (27-35) (human)
• Sepia (dye)