Caffeine Citrate Chemical Properties

Melting point:

173-176.5°

Density 

1.495±0.06 g/cm3(Predicted)

pka

1.74±0.10(Predicted)

Safety Information

Hazardous Substances Data

93390-81-9(Hazardous Substances Data)

Caffeine Citrate Usage And Synthesis

Description

Cerebyx was launched for the treatment of status epilepticus and for neurosurgery derived seizures. Fosphenytoin is rapidly converted by phosphatases to phenytoin. This compound is readily water soluble thus overcoming an important problem associated with Dilantin.

Originator

Warner-Lambert (USA)

Uses

Anticonvulsant.

Definition

ChEBI: Fosphenytoin is an imidazolidine-2,4-dione.

Manufacturing Process

By action of formaldehyde and hydrochloric acid on 5,5-diphenylhydantoin was prepared 3-hydroxymethyl-5,5-diphenyl-imidazolidine-2,4-dione which was converted by action PCl3 to 3-chloromethyl-5,5-diphenyl-imidazolidine-2,4- dione by action PCl3. Then the chlorine atom was substituted on P(O)(OBz)Ogroup by action of argentum salt of phosphoric acid dibenzyl ester. Removal of the protecting groups by hydrogenolysis gives the 2,4-imidazolidinedione, 5,5- diphenyl-3-((phosphonooxy)methyl)- (fosphenytoin).
In practice it is usually used as sodium salt.

brand name

Cerebyx (Parke-Davis).

Therapeutic Function

Antiepileptic, Anticonvulsant

Caffeine Citrate (93390-81-9)Related Product Information

• DIPHENAMID
• Fosphenytoin sodium
• doxenitoin
• 1,2-Ethanediamine,N2,N2-dimethyl-1-phenyl-,(1S)-(9CI)
• (R)-N2,N2-DIMETHYL-1-PHENYL-1,2-ETHANEDIAMINE
• Caffeine Citrate
• PHOSPHORIC DIBENZYL ESTER,5,5-DIPHENYL HYDANTOIN
• H-PHG-NH2 HCL
• FOSPHENYTOIN-2,4,5-13C3, 15N2, DISODIUM SALT 7H2O
• (R)-ALPHA-METHYL-PHENYLGLYCINAMIDE
• 5,5-Diphenylhydantoin