DIPHENAMID Chemical Properties

Melting point:

132-136 °C(lit.)

Boiling point:

381.97°C (rough estimate)

Density 

1.1700

refractive index 

1.5500 (estimate)

storage temp. 

0-6°C

form 

Huff Powder

pka

-0.68±0.70(Predicted)

color 

White

Water Solubility 

239.9mg/L(25 ºC)

Merck 

13,3339

BRN 

2052009

Stability:

Stable. Incompatible with strong oxidizing agents, strong bases.

CAS DataBase Reference

957-51-7

NIST Chemistry Reference

Fenam(957-51-7)

EPA Substance Registry System

Diphenamid (957-51-7)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-52/53

Safety Statements 

61

RIDADR 

UN3077(solid)

WGK Germany 

2

RTECS 

AB8050000

HS Code 

29242990

Hazardous Substances Data

957-51-7(Hazardous Substances Data)

Toxicity

LD50 orally in rats: 700 mg/kg (Bailey, White)

DIPHENAMID Usage And Synthesis

Description

Diphenamid is a white crystalline solid in various forms. Molecular weight= 239.34; Freezing/Meltingpoint = 135℃; Vapor pressure= 2.8 3 10 2 8 mmHg at20℃. Hazard Identification (based on NFPA-704 M RatingSystem): Health 1, Flammability 0, Reactivity 0. Veryslightly soluble in water

Chemical Properties

white or off-white powder

Uses

Selective preemergence herbicide used to control many broad-leaved weeds and most grass weeds in okra, cotton, peanuts tomatoes, sweet potatoes, potatoes, tobacco, fruits, turf and ornamentals.

Uses

Diphenamid is a pesticide found in representative agricultural produce (brown rice, orange, spinach and potatoes).

Uses

Herbicide.

Definition

ChEBI: Diphenamid is a diarylmethane.

General Description

Colorless to off-white crystals. Used as an herbicide.

Reactivity Profile

DIPHENAMID is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). DIPHENAMID is decomposed by strong base or acid.

Agricultural Uses

Herbicide: This material is used as a pre-emergent and selective herbicide for tomatoes, peanuts, alfalfa, soybeans, cotton and other crops. Not approved for use in the U.S. or EU countries. There are 18 global suppliers.

Trade name

DIF 4®; DYMID®[C]; ENIDE®[C]; FDN®; FENAM®; L 34314®; LILLY 34314®; RIDEON®; U 4513®; ZARUR®

Potential Exposure

AgriculturalChemical; Mutagen. This material is used as a preemergentand selective herbicide for tomatoes, peanuts, alfalfa, soybeans, cotton, and other crops.

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPRif heart action has stopped. Transfer promptly to amedical facility. When this chemical has been swallowed,get medical attention. Give large quantities of water andinduce vomiting. Do not make an unconscious personvomit.

Environmental Fate

Soil. Degradation of diphenamid in soils was reported to form desmethyldiphenamid via monodemethylation and a bidemethylated product of diphenamid (Somasundaram and Coats, 1991). The persistence of diphenamid under warm-moist soil conditions ranged from 3 to 6 months (Ashton and Monaco, 1991).
Groundwater. According to the U.S. EPA (1986), diphenamid has a high potential to leach to groundwater.
Plant. In strawberries, diphenamide was transformed via N-demethylation yielding Nmethyl-2,2-diphenylacetamide (Golab et al., 1966).
Photolytic. N-Methyl-2,2-diphenylacetamide and benzoic acid were reported as major photoproducts following the UV irradiation of diphenamid in distilled water (Cessna and Muir, 1991).
Chemical/Physical. Emits toxic fumes of nitrogen oxides when heated to decomposition (Sax and Lewis, 1987).

storage

Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Color Code—White: Corrosiveor Contact Hazard; Store separately in a corrosion-resistantlocation. Prior to working with this chemical you should betrained on its proper handling and storage. Store in tightlyclosed containers in a cool, well-ventilated area away fromstrong oxidizers, strong acids, strong alkalies.

Shipping

The name of this material is not in the DOT listof materials for label and packaging standards. However,based on regulations, it may be classified as anEnvironmentally hazardous substances, solid, n.o.s. Thischemical requires a shipping label of “CLASS 9.” It falls inHazard Class 9 and Packing Group III.[20, 21]

DIPHENAMID(957-51-7)Related Product Information

• Loperamide
• Loperamide
• Loperamide hydrochloride
• Doxapram
• DIPHENAMID
• Ropitoin
• racemoramide
• N,N-Dimethylacetamide
• Oxanilide
• 5,5-DIPHENYLHYDANTOIN-3-BUTYRIC ACID
• 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride
• Fluperamide
• PD 123319 ditrifluoroacetate
• Caffeine Citrate
• DEXTROMORAMIDE TARTRATE
• Desmethylmoramide
• DESMETHYL DIPHENAMID,diphenamid desmethyl
• α-Ethoxy-N-methyl-N-[2-[methyl(phenethyl)amino]ethyl]-α-phenylbenzeneacetamide