Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Pharmaceutical intermediates >  Heterocyclic compound >  Pyridine compound >  Hydroxypyridine >  Minodronic acid

Minodronic acid

Basic information Safety Supplier Related

Minodronic acid Basic information

Product Name:
Minodronic acid
Synonyms:
  • PHOSPHONIC ACID, (1-HYDROXY-2-IMIDAZO(1,2-A)PYRIDIN-3-YLETHYLIDENE)BIS-
  • 1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-bis(phosphonic acid)
  • (127657-42-5) minodronic acid
  • 1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)-1,1-ethanediyl]bis(phosphonic acid)
  • (1-Hydroxy-2-imidazo[1,2-A]pyridin-3-yl-1-ethyl)-1,1-bisphos phonate
  • Nsc725590
  • Bonoteo
  • BPH 261
CAS:
180064-38-4
MF:
C9H12N2O7P2
MW:
322.15
EINECS:
1592732-453-0
Product Categories:
  • API
Mol File:
180064-38-4.mol
More
Less

Minodronic acid Chemical Properties

Density 
1.97±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Aqueous Base (Slightly), Methanol (Slightly)
form 
Solid
pka
1.48±0.10(Predicted)
color 
White to Off-White
More
Less

Minodronic acid Usage And Synthesis

Description

Minodronic acid hydrate, a third-generation bisphosphonate, was approved and launched in Japan for the oral treatment of osteoporosis. Osteoporosis is a skeletal disorder characterized by low bone mass and structural deterioration of bone tissue resulting in bone fragility and increased susceptibility to fractures, particularly of the hip, spine, and wrist. It is the most common type of metabolic bone disease and a major health concern affecting 200 million women worldwide. Minodronic acid is the newest nitrogen-containing bisphosphonate to reach the market. In vitro, it inhibits recombinant human FPP synthase activity with similar potency as zoledronic acid (IC50 = 3 nM for both agents).
The most common adverse events associated with minodronic acid included stomach and abdominal discomfort, abdominal pain, decrease in blood calcium level, and gastritis. The chemical synthesis of minodronic acid starts with a condensation reaction of 2-aminopyridine with ethyl 4-bromo-3-oxobutyrate by means of sodium bicarbonate to produce 2-(imidazo[1,2-a]pyridin-3-yl)acetic acid ethyl ester, which is hydrolyzed to the corresponding carboxylic acid with potassium hydroxide. Treatment of the carboxylic acid intermediate with phosphorus acid and phosphorus trichloride followed by hydrolysis with hydrochloric acid gives minodronic acid.

Originator

Astellas Pharma (Japan)

Uses

Minodronic acid is developed for osteoporosis treatment.

brand name

Recalbon, Bonoteo

Minodronic acidSupplier

Zhongshan Haihong Medicine Co. Ltd Gold
Tel
0760-86925768 18824993998
Email
seas168@126.com
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Email
sales@BioChemBest.com
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Email
info@yuhaochemical.com
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Email
3001272453@qq.com