2-CHLORO-1,1,1-TRIFLUOROETHANE Chemical Properties

Melting point:

-105°C

Boiling point:

7°C

Density 

1.389

refractive index 

1.3090

form 

A liquid

CAS DataBase Reference

75-88-7(CAS DataBase Reference)

IARC

3 (Vol. 41, Sup 7, 71) 1999

EPA Substance Registry System

HCFC-133a (75-88-7)

Safety Information

Hazard Codes 

Xi

Risk Statements 

59

Safety Statements 

9-23-59

RIDADR 

1983

Hazard Note 

Irritant

TSCA 

T

HazardClass 

2.2

Hazardous Substances Data

75-88-7(Hazardous Substances Data)

Toxicity

LCLo inhalation in guinea pig: 33000ppm/5H

2-CHLORO-1,1,1-TRIFLUOROETHANE Usage And Synthesis

Chemical Properties

HCFC 133a is odorless with poor warning properties.

Uses

HCFC133a is a nonisolated intermediate in the production of halothane.

Definition

ChEBI: 2-Chloro-1,1,1-trifluoroethane is an organofluorine compound.

Synthesis Reference(s)

Journal of the American Chemical Society, 70, p. 758, 1948 DOI: 10.1021/ja01182a096

General Description

2-CHLORO-1,1,1-TRIFLUOROETHANE is a colorless, odorless gas. 2-CHLORO-1,1,1-TRIFLUOROETHANE is shipped as a liquid under its own vapor pressure. Contact with the liquid may cause frostbite to unprotected skin. 2-CHLORO-1,1,1-TRIFLUOROETHANE can asphyxiate by the displacement of air. Exposure of the container to fire or heat can cause 2-CHLORO-1,1,1-TRIFLUOROETHANE to rupture violently and rocket.

Reactivity Profile

2-CHLORO-1,1,1-TRIFLUOROETHANE is chemically inert in many situations, but can react violently with strong reducing agents such as the very active metals and the active metals. Undergoes oxidation with strong oxidizing agents and under extremes of temperature.

Health Hazard

Vapors may cause dizziness or asphyxiation without warning. Vapors from liquefied gas are initially heavier than air and spread along ground. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire may produce irritating, corrosive and/or toxic gases.

Fire Hazard

Some may burn but none ignite readily. Containers may explode when heated. Ruptured cylinders may rocket.

Safety Profile

A poison by inhalation. Experimental reproductive effects. Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits toxic fumes of F-.

Carcinogenicity

HCFC 133a was evaluated in a carcinogenesis screening study using Wistar-derived rats. The rats were given daily intubations of 300mg HCFC of body weight in corn oil for 52 weeks and held for a total of 125 weeks. In the males, there was a reduction in body weight gain and testicular size, also there was an increase in Leydig cell tumors and arrest of spermatogenesis. In the females, there was an increased incidence of uterine carcinomas.

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