Forodesine Chemical Properties

Boiling point:

613.5±65.0 °C(Predicted)

Density 

2.01

storage temp. 

Hygroscopic, Refrigerator, under inert atmosphere

solubility 

PBS (pH 7.2): 5 mg/ml

form 

A crystalline solid

pka

13.88±0.70(Predicted)

color 

Light brown to gray

Forodesine Usage And Synthesis

Description

Forodesine is a purine nucleoside analog and purine nucleoside phosphorylase (PNP) inhibitor (IC₅₀s = 1.19, 0.48, 1.24, 0.66, and 1.57 nM for human, mouse, rat, monkey, and dog PNP, respectively). It inhibits phytohemagglutinin A-, mixed lymphocyte reaction-, or IL-2-induced proliferation of isolated human peripheral blood lymphocytes (PBLs; IC₅₀s = <0.1-0.38 μM) in the presence, but not absence, of 2’-deoxyguanosine (dGuo). Forodesine inhibits proliferation of CEM-SS T cell acute lymphoblastic leukemia (T-ALL) cells. In vivo, forodesine (10 mg/kg) prolongs survival in the hu-PBL-SCID mouse model of xenogeneic graft versus host disease (GVHD).

Uses

Treatment of T-Cell malignancies such as acute lymphoblastic leukemia (ALL) and cutaneous T-cell lymphoma (CTCL) Fodosine.

Uses

Fodosine is a 23-pM inhibitor of bovine purine nucleoside phosphorylase (PNP) specifically designed as a transition state mimic.

Definition

ChEBI: Immucillin H is a pyrrolopyrimidine and a dihydroxypyrrolidine.

Forodesine(209799-67-7)Related Product Information

• Polyvinylpyrrolidone
• Crospovidone
• N-Methyl-2-pyrrolidone
• N-Vinyl-2-pyrrolidone
• Povidone iodine
• 1,5-DIHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE
• Forodesine
• METHYL-2-PYRROLIDONE