5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)-
5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)- Basic information
- Product Name:
- 5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)-
- Synonyms:
-
- 5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)-
- 8-Hydroxy-7-[(6-sulfo-2-naphthyl)azo]-5-quinolinesulfonicacid
- NSC 87877
- XGMFVZOKHBRUTL-QURGRASLSA-N
- 5-Quinolinesulfonicacid, 8-hydroxy-7-[2-(6-sulfo-2-naphthalenyl)diazenyl]-
- NSC 87877(free acid)
- (7e)-8-oxo-7-[(6-sulfonaphthalen-2-yl)hydrazinylidene]quinoline-5-sulfonic Acid
- 8-Hydroxy-7-((6-sulfonaphthalen-2-yl)diazenyl)quinoline-5-sulfonic acid
- CAS:
- 56990-57-9
- MF:
- C19H13N3O7S2
- MW:
- 459.45
- Product Categories:
-
- Potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP).
- Mol File:
- 56990-57-9.mol
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5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)- Chemical Properties
- storage temp.
- Store at +4°C
- solubility
- ≥45.9 mg/mL in DMSO; insoluble in EtOH; ≥16.6 mg/mL in H2O with ultrasonic
- form
- Powder
- color
- Light brown to black
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5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)- Usage And Synthesis
Uses
NSC 87877 is an inhibitor of SHP2 and SHP1 protein tyrosine phosphatases
Definition
ChEBI: 8-oxo-7-[(6-sulfo-2-naphthalenyl)hydrazinylidene]-5-quinolinesulfonic acid is a naphthalenesulfonic acid.
Biological Activity
Potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC 50 values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μ M for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.
storage
Store at +4°C
5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)-Supplier
J & K SCIENTIFIC LTD.
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
VDM Biochemicals
- Tel
- 0330-2528181
- sales@vdmbio.com
Guangzhou Isun Pharmaceutical Co., Ltd
- Tel
- 020-39119399 18927568969
- isunpharm@qq.com
AdooQ Bioscience CHINA
- Tel
- 025-58849295 18951903616;
- info@adooq.cn
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- 5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)-
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