5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)- Chemical Properties

storage temp. 

Store at +4°C

solubility 

≥45.9 mg/mL in DMSO; insoluble in EtOH; ≥16.6 mg/mL in H2O with ultrasonic

form 

Powder

5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)- Usage And Synthesis

Uses

NSC 87877 is an inhibitor of SHP2 and SHP1 protein tyrosine phosphatases

Definition

ChEBI: 8-oxo-7-[(6-sulfo-2-naphthalenyl)hydrazinylidene]-5-quinolinesulfonic acid is a naphthalenesulfonic acid.

Biological Activity

Potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC 50 values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μ M for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.

storage

Store at +4°C

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