Basic information Safety Supplier Related

(10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE

Basic information Safety Supplier Related

(10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE Basic information

Product Name:
(10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE
Synonyms:
  • NSC 146109 HYDROCHLORIDE
  • (10-Methylanthracen-9-yl)methyl Carbamimidothiote Hydrochloride
  • (10-Methylanthracen-9-yl)methyl carbamimidothioate hydrochloride
  • (10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE
  • (10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride
  • NSC 146109
  • NSC 146109 (HYDROCHLORIDE);XI-011
  • XI-011
CAS:
59474-01-0
MF:
C17H17ClN2S
MW:
316.85
Product Categories:
  • Caspases/Apoptosis
  • Cell Cycle Regulation
Mol File:
59474-01-0.mol
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(10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE Chemical Properties

storage temp. 
Desiccate at RT
solubility 
Soluble to 10 mM in ethanol and to 100 mM in DMSO
form 
Powder
color 
White to yellow
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(10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE Usage And Synthesis

Uses

This molecule inhibits MDMX expression in breast cancer cells through activating p53 resulting in apoptosis in cancer cells.

Biological Activity

Cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription. Increases levels of endogenous p53 in tumor cells and protects p53 from Mdm2-mediated degradation. Displays some selectivity for tumor cells vs. normal cells in an MTT cell viability assay.

(10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDESupplier

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