Basic information Safety Supplier Related

(10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE

Basic information Safety Supplier Related

(10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE Basic information

Product Name:
(10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE
Synonyms:
  • NSC 146109 HYDROCHLORIDE
  • (10-Methylanthracen-9-yl)methyl Carbamimidothiote Hydrochloride
  • (10-Methylanthracen-9-yl)methyl carbamimidothioate hydrochloride
  • (10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE
  • (10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride
  • NSC 146109
  • NSC 146109 (HYDROCHLORIDE);XI-011
  • XI-011
CAS:
59474-01-0
MF:
C17H17ClN2S
MW:
316.85
Product Categories:
  • Caspases/Apoptosis
  • Cell Cycle Regulation
Mol File:
59474-01-0.mol
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(10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE Chemical Properties

storage temp. 
Desiccate at RT
solubility 
Soluble to 10 mM in ethanol and to 100 mM in DMSO
form 
Powder
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(10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE Usage And Synthesis

Uses

This molecule inhibits MDMX expression in breast cancer cells through activating p53 resulting in apoptosis in cancer cells.

Biological Activity

Cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription. Increases levels of endogenous p53 in tumor cells and protects p53 from Mdm2-mediated degradation. Displays some selectivity for tumor cells vs. normal cells in an MTT cell viability assay.

(10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDESupplier

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