8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT
8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT Basic information
- Product Name:
- 8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT
- Synonyms:
-
- 5-Quinolinesulfonicacid,8-hydroxy-7-[(6-sulfo-2-naphthalenyl)azo]-,disodiumsalt
- 7-(6-Sulfo-2-naphthylazo)-8-hydroxyquinoline-5-sulfonicacid,disodiumsalt
- NSC-87877(sodium salt)
- 8-hydroxy-7-[(6-sulfo-2-naphthalenyl)azo]-5-quinolinesulfonicacidisodium
- 7-(6-SULFO-2-NAPHTHYLAZO)-8-HYDROXYQUINOLINE-5-SULFONIC ACID SODIUM SALT
- 8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT
- NAPHTHYLAZOXINE 6S
- NAPHTHYLAZOXINE S
- CAS:
- 56932-43-5
- MF:
- C19H11N3Na2O7S2
- MW:
- 503.42
- EINECS:
- 260-449-5
- Mol File:
- 56932-43-5.mol
8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT Chemical Properties
- storage temp.
- Inert atmosphere,Room Temperature
- form
- Solid
- color
- Brown to black
- Water Solubility
- water: 10mg/mL
- EPA Substance Registry System
- 5-Quinolinesulfonic acid, 8-hydroxy-7-[(6-sulfo-2-naphthalenyl)azo]-, disodium salt (56932-43-5)
Safety Information
- Safety Statements
- 24/25
MSDS
- Language:English Provider:ACROS
8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT Usage And Synthesis
Chemical Properties
dark red to red-brown powder
Uses
NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26)[2].
Biological Activity
Cell permeable: yes', 'Primary Target
SHP1/2 PTPase', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 355 nM and 318 nM against SHP-1 and SHP-2 protein tyrosine phosphatases, respectively
in vivo
NSC-87877 (30?mg/kg, IP once daily for 15 days) possesses excellent anti- neuroblastoma activity[3].
| Animal Model: | Intrarenal neuroblastoma (NB) tumor mouse model in female nude mice[3]. |
| Dosage: | 30?mg/kg. |
| Administration: | IP once daily for 15 days. |
| Result: | Significantly inhibited NB tumor growth. |
References
[1] Chen L, et al. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol. 2006 Aug;70(2):562-70. DOI:10.1124/mol.106.025536
[2] Song M, et al. NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). Biochem Biophys Res Commun. 2009 Apr 17;381(4):491-5. DOI:10.1016/j.bbrc.2009.02.069
[3] Y Shi, et al. NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death Dis. 2015 Aug 6;6(8):e1841. DOI:10.1038/cddis.2015.207
8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALTSupplier
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8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT(56932-43-5)Related Product Information
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- 7-Aminoquinoline
- 2-Aminophenol-4-sulfonic acid
- 4-HYDROXYBENZENESULFONIC ACID SODIUM SALT HYDRATE
- 4-Hydroxybenzenesulfonic acid
- 8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT
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- 8-HYDROXYQUINOLINE-5-SULFONIC ACID MONOHYDRATE
- 4-HYDROXYBENZENESULFONIC ACID SODIUM SALT DIHYDRATE
- NAPHTHYLAZOXINE
- 8-HYDROXY-7-(4-SULFO-1-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID, DISODIUM SALT
- quinoline-5-sulphonic acid