ANKAFLAVIN Chemical Properties

Boiling point:

590.7±50.0 °C(Predicted)

Density 

1.15±0.1 g/cm3(Predicted)

storage temp. 

4°C, protect from light

solubility 

Soluble in DMSO

form 

Solid

pka

10.75±0.60(Predicted)

color 

Light yellow to yellow

Major Application

(Pharmaceutical small molecule)

InChIKey

AQTJNEHGKRUSLT-ODTNPMSZSA-N

SMILES

C1(/C=C/C)OCC2C(=O)[C@]3(C)OC(=O)[C@H](C(=O)CCCCCCC)[C@@]3([H])CC=2C=1

Safety Information

Storage Class

11 - Combustible Solids

ANKAFLAVIN Usage And Synthesis

Description

Ankaflavin (AK), isolated from Monascus-Fermented red rice, is a PPARγ agonist with anti-inlfammatory activity. Ankaflavin is an active compound having anti-inflammatory, anti-cancer, antiatherosclerotic, and hypolipidemic effects.

Anti-cancer Activity

Ankaflavin was found to be toxic to human cancer cell lines Hep G2 and A549 with a similar IC50 value of 15 μg/mL, while it posed no significant toxicity to normal MRC-5 and WI-38 cells at the same concentration.Ankaflavin exhibits selective cytotoxic effect and induces cell death on cancer cells.

Description

Ankaflavin is a microbial metabolite that has been found in M. ruber and has diverse biological activities.1,2,3 It induces cytotoxicity in HepG2 hepatic carcinoma and A549 lung cancer cells (IC50 = ~15 µg/ml for both).1 Ankaflavin (15 µg/ml) induces cell cycle arrest at the G0 phase in HepG2 cells. It reduces nitric oxide (NO) production in LPS-stimulated RAW 264.7 macrophages when used at concentrations of 5, 10, and 15 µg/ml.2 Ankaflavin (10 µM) increases lipolysis in 3T3-L1 adipocytes matured by isobutylmethylxanthine (IBMX; Item No. 13347), dexamethasone (Item No. 11015), and insulin.3 In vivo, ankaflavin (5 mg/kg per day) reduces blood glucose and serum insulin levels in mice fed a high-fat diet.WARNING This product is not for human or veterinary use.

ANKAFLAVIN(50980-32-0)Related Product Information

• Edible essence
• Disodium nucleotide
• Sodium erythorbate
• menisdaurin
• Camphene
• Muscone
• ALPHA-CARYOPHYLLENE
• 4-Methoxybenzoic acid 2-(4-hydroxyphenyl)ethyl ester
• MONASCIN
• Xanthiside
• Xanthiazone
• Hydroxycitric acid
• GLUCOTROPAEOLIN
• Z-LIGUSTILIDE
• L-(+)Sodium glutamate