4-Chlorophenylacetylene Chemical Properties

Melting point:

45-47 °C(lit.)

Boiling point:

79-82 °C (23 mmHg)

Density 

1.24 g/cm3(Temp: 50 °C)

Flash point:

10 °C

storage temp. 

Sealed in dry,2-8°C

solubility 

Acetone, Chloroform (Slightly), Dichloromethane, DMF, DMSO, Ethanol, Ethyl Acetate)

form 

Crystalline Mass

color 

Yellow to pale brown

Water Solubility 

Insoluble in water. Soluble in acetone, chloroform, dichloromethane, DMF, DMSO, ethanol, ethyl acetate, hexane, methanol,THF and toluene.

Stability:

Light Sensitive

InChIKey

LFZJRTMTKGYJRS-UHFFFAOYSA-N

CAS DataBase Reference

873-73-4(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 1-chloro-4-ethynyl-(873-73-4)

Safety Information

Hazard Codes 

F,Xi

Risk Statements 

36/37/38-11

Safety Statements 

16-26-36-37/39

RIDADR 

UN 1325 4.1/PG 2

WGK Germany 

3

Hazard Note 

Irritant/Keep Cold

HazardClass 

FLAMMABLE

HazardClass 

4.1

PackingGroup 

Ⅱ

HS Code 

29039990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

4-Chlorophenylacetylene Usage And Synthesis

Chemical Properties

White Crystalline Solid

Uses

4-Chlorophenylacetylene is used as pharmaceutical intermediate.

Synthesis Reference(s)

Synthesis, p. 728, 1984 DOI: 10.1055/s-1984-30947

General Description

1-Chloro-4-ethynylbenzene undergoes standard Sonogashira reaction with iodophenyl groups on the film surfaces via the formation of C?C bonds.

4-Chlorophenylacetylene(873-73-4)Related Product Information

• Chlorphenamine maleate
• 3-Ethynylaniline
• Amlodipine Besylate
• Phenylacetylene
• Diphenylacetylene
• Acetylene
• 1-BUTEN-3-YNE
• Chlorantraniliprole
• 1,2,4-Trichlorobenzene
• Trimethylsilylacetylene
• 1,2-Dichlorobenzene
• 4-NITROPHENYLACETYLENE
• Difluorochloromethane
• IMP. A (EP): CHLORPHENAMINE (USP: CHLORPHENIRAMINE)
• p-Dichlorobenzene
• 3-CHLOROPHENYLACETYLENE
• 2-CHLOROPHENYLACETYLENE,2-Chlorophenylacetylene 98%
• (4-CHLOROPHENYLETHYNYL)TRIMETHYLSILANE