Etimizol
Etimizol Basic information
- Product Name:
- Etimizol
- Synonyms:
-
- Etimizol
- Antiffine
- Ethimizole
- Ethymisol
- Ethymisole
- Ethymizol
- Etimizole
- Ethylnorantifein
- CAS:
- 64-99-3
- MF:
- C9H14N4O2
- MW:
- 210.23
- Mol File:
- 64-99-3.mol
Etimizol Chemical Properties
- Melting point:
- 143-144℃
- Boiling point:
- 563.4±35.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Ethanol: ≥ 33.33 mg/mL (158.54 mM)
- form
- Solid
- pka
- 14.22±0.46(Predicted)
- color
- White to off-white
Etimizol Usage And Synthesis
Uses
Etimizol(Ethymisole; Antiffine; Ethylnorantifein) was shown to relieve amnesia effectively in the origin of which there is the hypoxic component (hypobaric hypoxia, actinomycin D, mechanical injury of the brain). Etimizol can decrease the K-+ permeability of neurons' membrane during action potential.
in vivo
The time interval between administration ofetimizol (3 mg/kg) and the onset of learning varied between 0.5 and 3 h in the several series. Etimizol (Ethymisole) did not facilitate the learning in rats whatever the time of administration and biological modality of reinforcement [1]. After administration of Etimizol (Ethymisole) at doses of 10 or 1 mg/loop mean residence time of etimizol in the loop was 20.1 and 7.6 min, respectively, with mean standard deviation being 3.1 and 0.8, respectively [2]. Extracellular application of 5--10 mM/L Etimizol (Ethymisole) exerted a specific effect on the giant neurons of the Coretus corneus isolated nervous system: action potential duration increased significantly, speed of development of its descending phase decreased, as well as the trace hyperpolarization amplitude [3].
References
[1] Borisova GIu. Effect of etimizol on instrumental learning in rats. Biull Eksp Biol Med. 1985 Jun;99(6):705-6. PMID:4016262
[2] Trnovec T, et al. Etimizol absorption from the small intestine in dogs: the dependence on dosage. Biull Eksp Biol Med. 1986 Dec;102(12):729-30. PMID:3801627
[3] Vislobokov AI, et al. Elektrophysiological parameters of mollusk neurons under the influence of etimizol. Fiziol Zh SSSR Im I M Sechenova. 1975 Jun;61(6):917-24. PMID:1132537
EtimizolSupplier
- Tel
- 021-58950125
- info@chemexpress.com
- Tel
- +1 (866) 930-6790
- info@adooq.com
- Tel
- 021-58930698 15921516558
- zhangyichao84@126.com
- Tel
- 025-58849295 18951903616;
- info@adooq.cn
- Tel
- 18620099427
- amy@howeipharm.com