antibiotic 1233A Chemical Properties

Boiling point:

516.6±15.0 °C(Predicted)

Density 

1.101±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMSO: soluble

form 

powder

pka

4.98±0.33(Predicted)

color 

White

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Safety Information

WGK Germany 

3

RTECS 

YQ1170000

antibiotic 1233A Usage And Synthesis

Description

Hymeglusin (29066-42-0) is an inhibitor of eukaryotic mevalonate biosynthesis via inhibition of HMG-CoA synthase, IC50=0.12 μM.1 Acts via covalent modification of the active site Cys129.1,2 Inhibits cholesterol biosynthesis in rats (45% at 25 mg/Kg).1 Also inhibits bacterial HMG-CoA synthase.3 Inhibits dengue virus replication.4

Uses

Hymeglusin is an irreversible HMG-CoA synthase inhibitor.

Definition

ChEBI: Hymeglusin is a long-chain fatty acid.

storage

+4°C

References

1) Greenspan et al. (1987), Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699; Proc. Natl. Acad. Sci. USA, 84 7488 2) Tomoda et al. (2004), Binding site for fungal beta-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase; Biochem. Biophys. Acta, 1636 22 3) Skaff et al. (2012), Biochemical and structural basis for inhibition of Enterococcis faecalis hydroxymethylglutaryl-CoA synthase, mvaS, by hymeglusin; Biochemistry, 51 4713 4) Rothwell et al. (2009), Cholesterol biosynthesis modulation regulates dengue viral replication; Virology, 389 8

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