6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID Chemical Properties

storage temp. 

Sealed in dry,Room Temperature

solubility 

ethanol: 2.5 mg/mL, soluble

form 

crystalline solid or supercooled liquid

color 

White

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 6 months.

Safety Information

WGK Germany 

3

6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID Usage And Synthesis

Description

AH 6809 is an EP and DP receptor antagonist with nearly equal affinity for the cloned human EP₁, EP₂, EP₃-III, and DP₁ receptors. AH 6809 blocks the PGE₂-induced accumulation of cAMP in COS cells transfected with the human EP₂ receptor. It also blocks the accumulation of Ca²⁺ in Xenopus oocytes expressing the human EP₁ receptor. In the human and guinea pig, the activity profile of AH 6809 is similar to that of SC-19220, but it is somewhat more potent. In the mouse, AH 6809 has the highest affinity for the EP₂ receptor, but also acts as a weak ligand at the murine EP₁ and DP₁ receptors. In whole human platelets, AH 6809 is an effective antagonist of the antiaggregatory actions of PGD₂, but not PGI₂, with an EC₅₀ of about 5 x 10⁻⁵ M.

Uses

AH-6809 is a prostaglandin E2 receptor antagonist.

Definition

ChEBI: 9-oxo-6-propan-2-yloxy-2-xanthenecarboxylic acid is a member of xanthones.

Biological Activity

Antagonist at prostaglandin EP 1 (pA 2 = 6.8 ) and EP 2 (K i = 350 nM) receptors. Also weakly inhibits DP receptors (pA 2 = 4.45).

storage

Store at RT

References

1) Coleman in Prostaglandins and Related Substances: A Practical Approach; ILR Press, Oxford and Washington D.C. 1987, pg 267

6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID(33458-93-4)Related Product Information

• METYRAPONE
• Lovastatin
• URB597
• NAGLY
• Titanium diisopropoxide bis(acetylacetonate)
• Aluminium isopropoxide
• Oxygen-fluorine acid
• Xanthone
• 4-(3-HYDROXYPHENOXY)BENZOIC ACID
• 6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID
• 3-acetyl-4-hydroxybenzoic acid
• 4-(3-METHOXY-PHENOXY)-BENZALDEHYDE