Basic information Description In vitro In vivo Safety Supplier Related
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URB597

Basic information Description In vitro In vivo Safety Supplier Related

URB597 Basic information

Product Name:
URB597
Synonyms:
  • N-Cyclohexylcarbamic acid 3'-(aminocarbonyl)[1,1'-biphenyl]-3-yl ester
  • 3'-CarbaMoyl-[1,1'-biphenyl]-3-yl cyclohexylcarbaMate
  • N-cyclohexylcarbamic acid [3-(3-carbamoylphenyl)phenyl] ester
  • URB 597 NEW
  • FAAH inhibitor
  • KDS-4103;URB-597;FAAH INHIBITOR II
  • 3-(3-carbaMoylphenyl)phenyl N-cyclohexylcarbaMate
  • KDS 4103 N-Cyclohexylcarbamic acid 3'-(aminocarbonyl)[1,1'-biphenyl]-3-yl ester
CAS:
546141-08-6
MF:
C20H22N2O3
MW:
338.4
EINECS:
637-274-1
Product Categories:
  • Pharmaceutical intermediate
  • Inhibitors
  • HFC80014
  • Inhibitor
  • Chemical for Research
  • Research Chemical
Mol File:
546141-08-6.mol
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URB597 Chemical Properties

Boiling point:
533.2±50.0 °C(Predicted)
Density 
1.23
storage temp. 
2-8°C
solubility 
DMSO: ~14 mg/mL, soluble
form 
powder
pka
11.74±0.20(Predicted)
color 
white
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Safety Information

Hazard Codes 
N
Risk Statements 
50/53
Safety Statements 
22-24/25-60-61
RIDADR 
UN 3077 9/PG 3
WGK Germany 
3

MSDS

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URB597 Usage And Synthesis

Description

URB597 is a potent, orally bioavailable FAAH inhibitor with IC50 of 4.6 nM, with no activity on other cannabinoid-related targets. Phase 1.

In vitro

URB597 binds in the hydrophobic pocket and catalytic core of FAAH that connects the active site residues to the membrane surface of FAAH. URB597 inhibits FAAH activity in human liver microsomes with IC50 of 3 nM. URB597 reduces the expression of the LPS-induced enzymes cyclo-oxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS; NOS2) in primary rat microglial cell, with a concomitant reduction in the release of the inflammatory mediators prostaglandin E2 (PGE2) and (NO) nitric oxide. URB597 evokes Ca2+ entry in HEK293-F Cells transiently expressing human or rat TRPA1 gene. URB597 also activates Ca2+ entry in rat DRG neurons natively expressed TRPA1 channels.

In vivo

URB597 inhibits [3H]anandamide hydrolysis in rat brain membranes with a parallel increase in brain anandamide, OEA, and PEA content by inhibition of FAAH. URB597 enhances the hypothermia effect induced by ethanolamide by inhibiting FAAH.When delivered intraperitonealy (0.3 mg/kg) URB597 reduces allodynia and hyperalgesia through cannabinoid CB1 and CB2 receptor-mediated analgesia in rats with inflammatory pain.URB597 reduces the reduction in body weight gain and sucrose intake induced by the chronic mild stress in rats through inhibition of brain FAAH activity. URB597 could reverse most depressive-like symptoms induced by adolescent THC exposure in femal rats.

URB597Supplier

ChemFuture PharmaTech (Jiangsu) Ltd
Tel
0510-85386188;0510-85386988-8021
Email
Sales@chemfuture.cn;Sales@chemfuture.cn
Products Intro
Product Name:3'-carbaMoylbiphenyl-3-ylcyclohexylcarbaMate
CAS:546141-08-6
Remarks:CF0491G
Chembest Research Laboratories Limited
Tel
021-20908456-
Email
sales@BioChemBest.com
Products Intro
Product Name:KDS 4103
CAS:546141-08-6
Purity:>98% Package:10mg;50mg;100mg;500mg;1g;5g;10g Remarks:C14551
VDM Biochemicals
Tel
0330-2528181
Email
sales@vdmbio.com
Products Intro
Product Name:FAAH Inhibitor II; URB597
CAS:546141-08-6
Purity:>=98%
Nanjing Chemlin Chemical Co., Ltd
Tel
Email
info@chemlin.com.cn
Products Intro
Product Name:3'-CarbaMoyl-biphenyl-3-yl cyclohexylcarbaMate
CAS:546141-08-6
Purity:97%. Package:5g;1kg;10kg
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202- ;021-54308259-
Email
info@hanhonggroup.com;info@hanhonggroup.com
Products Intro
Product Name:URB597
CAS:546141-08-6
Purity:95% Remarks:AB04537