Naphth[2,3,-b]oxiren-2(1aH)-one, 4,
Naphth[2,3,-b]oxiren-2(1aH)-one, 4, Basic information
- Product Name:
- Naphth[2,3,-b]oxiren-2(1aH)-one, 4,
- Synonyms:
-
- Isonardosinone
- Naphth[2,3,-b]oxiren-2(1aH)-one, 4,
- (1aS)-4,5,6,6a,7,7aβ-Hexahydro-7α-(1-hydroxy-1-methylethyl)-6β,6aβ-dimethylnaphth[2,3-b]oxiren-2(1aβH)-one
- Naphth[2,3-b]oxiren-2(1aH)-one, 4,5,6,6a,7,7a-hexahydro-7-(1-hydroxy-1-methylethyl)-6,6a-dimethyl-, (1aS,6R,6aR,7S,7aS)-
- CAS:
- 27062-01-7
- MF:
- C15H22O3
- MW:
- 250.33
- Mol File:
- 27062-01-7.mol
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Naphth[2,3,-b]oxiren-2(1aH)-one, 4, Chemical Properties
- Boiling point:
- 381.0±25.0 °C(Predicted)
- Density
- 1.15±0.1 g/cm3(Predicted)
- pka
- 14.68±0.29(Predicted)
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Naphth[2,3,-b]oxiren-2(1aH)-one, 4, Usage And Synthesis
Uses
Isonardosinone is a nardosinone-type sesquiterpenes, which can be isolated from Valerianaceae. Isonardosinone inhibits NF-κB and MAPK signaling pathway, suppresses expression of iNOS and cyclooxygenase-2 (COX-2) in Lipopolysaccharides (HY-D1056)-induced BV2 microglia, exhibits anti-inflammatory activity[1].
References
[1] Ko W, et al., Nardosinone-Type Sesquiterpenes from the Hexane Fraction of Nardostachys jatamansi Attenuate NF-κB and MAPK Signaling Pathways in Lipopolysaccharide-Stimulated BV2 Microglial Cells. Inflammation. 2018 Aug;41(4):1215-1228. DOI:10.1007/s10753-018-0768-9
Naphth[2,3,-b]oxiren-2(1aH)-one, 4,Supplier
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