Demethyl tetrandrine Chemical Properties

Melting point:

212-4°C (dec. ).

Boiling point:

709.7±60.0 °C(Predicted)

Density 

1.204±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly)

form 

Solid

pka

9.38±0.20(Predicted)

color 

Off-White to Pale Beige

Demethyl tetrandrine Usage And Synthesis

Uses

Fangchinoline is an isolate from Stephania Tetrandra that shows anti-cancer activity. It inhibits breast adenocarcinoma proliferation through apoptosis induction. In addition, it has been shown to inhibit HIV-Type 1 replication.

Description

Thalictrum rugosum Ait also contains this alkaloid which is dextrorotatory with [o:lbo + 128° (MeOH). The ultraviolet spectrum of this base consists of a single absorption maximum at 283 flI/J..

Uses

Fangchinoline is an isolate from Stephania Tetrandra that shows anti-cancer activity. It inhibits breast adenocarcinoma proliferation through apoptosis induction. In addition, it has been shown to inhibit HIV-Type 1 replication.

target

DNA/RNA Synthesis

References

Mitscher et al., Chem. Commun., 589 (1971)

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