4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile Chemical Properties

Boiling point:

616.3±55.0 °C(Predicted)

Density 

1.45

storage temp. 

2-8°C

solubility 

DMF: 1 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 1 mg/ml

form 

A crystalline solid

pka

4.80±0.10(Predicted)

4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile Usage And Synthesis

Description

Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2; IC₅₀ = 0.05 μM). It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC₅₀s = >40, 180, >400, 110, and >400 μM, respectively). Tpl2 kinase inhibitor inhibits LPS-induced TNF-α production in isolated human monocytes and whole blood (IC₅₀s = 0.7 and 8.5 μM, respectively). It enhances differentiation induced by 1,25-dihydroxy vitamin D₃ (calcitriol; ) in HL-60 and U937 leukemia cells when used at a concentration of 5 μM. Tpl2 kinase inhibitor (5 μM) inhibits the proliferation of KG-1a leukemia cells.

Uses

TC-S 7006 is a Tpl2 kinase inhibitor.

storage

Store at -20°C

4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile(871307-18-5)Related Product Information

• 3-Aminopyridine
• 2-Aminopyridine
• Glycine
• 4-Dimethylaminopyridine
• ALTRENOGEST
• CHLOROPHENYLSILANE 97
• 4,4'-DDT
• 3,4'-DIAMINODIPHENYLMETHANE
• AMINO ACIDS
• Difluorochloromethane
• 3-Chloro-4-fluoroaniline
• 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile