Basic information Safety Supplier Related

SPIROXATRINE

Basic information Safety Supplier Related

SPIROXATRINE Basic information

Product Name:
SPIROXATRINE
Synonyms:
  • SPIROXATRINE
  • R 5188
  • (+/-)-8-[(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)METHYL]-1-PHENYL-1,3,8-TRIAZA-SPIRO[4,5]DECAN-4-ONE
  • 8-[(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)METHYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4,5]DECAN-4-ONE
  • SPIROXATRINE (R 5188) SELECTIVE SEROTONI N 5
  • R 5188, (±)-8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triaza-spiro[4,5]decan-4-one
  • Spiroxatrine (R 5188)
  • 8-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
CAS:
1054-88-2
MF:
C22H25N3O3
MW:
379.45
Product Categories:
  • Serotonin receptor
Mol File:
1054-88-2.mol
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SPIROXATRINE Chemical Properties

Melting point:
215.8-218.0 °C
Boiling point:
602.8±55.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
0.1 M HCl: moderately soluble
form 
powder
pka
15.03±0.20(Predicted)
color 
white
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Safety Information

WGK Germany 
3

MSDS

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SPIROXATRINE Usage And Synthesis

Uses

Spiroxatrine (R 5188) is a SR-1A antagonist.

Definition

ChEBI: 8-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one is a member of imidazolidines.

Biological Activity

5-HT 1A antagonist. More active and selective than spiperone. Also a very potent α 2C adrenergic receptor antagonist.

in vivo

Spiroxatrine (1-25 ug for i.p., 5 days) increases hindpaw withdrawal latencies to thermal and mechanical stimulation in the nerve injury rat and Carrageenan (HY-125474)-induced rat inflammation model[3].
Spiroxatrine (4 mg/kg/day for i.p., 5 mins) increases the voluntary oral ethanol intake induced by Fluoxetine (HY-B0102) in the selectively bred alcohol-preferring P line of rats [4].

Animal Model:The nerve injury rat model and Carrageenan (HY-125474)-induced rat inflammation model[3]
Dosage:1, 10, 25 ug, 5 days
Administration:Intraperitoneal injection (i.p.)
Result:Increased hindpaw withdrawal latencies to thermal and mechanical stimulation.
Animal Model:Fluoxetine (HY-B0102) -induced reduction of ethanol Intake by the P Line of rats[4]
Dosage:4 mg/kg/day, 5 mins
Administration:Intraperitoneal injection (i.p.)
Result:Increased the voluntary oral ethanol intake induced by Fluoxetine (HY-B0102) in the selectively bred alcohol-preferring P line of rats.

IC 50

α2-adrenergic receptor; 5-HT1A Receptor: 3.94 nM (Ki); 5-HT1B/D Receptor: 224000 nM (Ki); 5-HT2 Receptor: 118.5 nM (Ki)

SPIROXATRINESupplier

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Email
info@chemlin.com.cn
EMMX Biotechnology LLC
Tel
888-539-0666
Email
info@emmx.com
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Email
3008007409@qq.com
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
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SPIROXATRINE(1054-88-2)Related Product Information