(1-Methyl-4-piperidinyl)methanamine Chemical Properties

Melting point:

0°C

Boiling point:

80 °C

Density 

0.901±0.06 g/cm3(Predicted)

Flash point:

0°C

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

liquid

pka

10.13±0.29(Predicted)

color 

Pale yellow

InChI

InChI=1S/C7H16N2/c1-9-4-2-7(6-8)3-5-9/h7H,2-6,8H2,1H3

InChIKey

AGTPSAZJSOQXHJ-UHFFFAOYSA-N

SMILES

N1(C)CCC(CN)CC1

CAS DataBase Reference

7149-42-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

C,Xi

Risk Statements 

34-20/22-22-10

Safety Statements 

26-36/37/39-45-23

RIDADR 

2735

WGK Germany 

1

Hazard Note 

Corrosive

HazardClass 

IRRITANT

HS Code 

29333990

(1-Methyl-4-piperidinyl)methanamine Usage And Synthesis

Chemical Properties

Colourless liquid

Uses

(1-methyl-4-piperidinyl)methanamine is a reagent used in the synthesis of novel indole-carboxamides which are inhibitors of neurotropic alphavirus.

Synthesis

1-Methylisonipecotamide (6.75g, 47. 5MMOLES) was dissolved in anhydrous THF (350mL), and the resulting mixture was added in portions to a stirred slurry of lithium aluminum hydride (1.8g, 47. 5mmoles) in anhydrous THF (100 mL) at 0 ℃ under nitrogen. The mixture was stirred at 0 ℃ for 30min and then heated at 66 ℃ for 25h under nitrogen. Distilled water (1.88 mL) was added dropwise to the stirred mixture at 0 ℃, followed by 20 percent aqueous sodium hydroxide (1.42 mL), and then distilled water (6.75mL), and the mixture was stirred for 15 min. The mixture was filtered, and the solids were washed with THF and dichloromethane. The combined filtrates were evaporated to dryness and chromatographed on a silica gel column (30x5 cm) using 15 percent-20 percent (10 percent CONC. ammonium hydroxide in METHANOL)-DICHLOROMETHANE as the eluant to give (1-Methyl-4-piperidinyl)methanamine (0.678g, 11percent).

(1-Methyl-4-piperidinyl)methanamine(7149-42-0)Related Product Information

• CALYCANTHINE
• SPIPERONE
• FLUSPIRILENE
• SPIROXATRINE
• (R)-3-Aminoquinuclidine dihydrochloride
• befiradol
• (1-METHYL-2-PIPERIDINYL)METHANAMINE
• 1-benzyl-4-(ethylamino)piperidine-4-carboxamide
• Fenspiride hydrochloride
• N-benzyl-1-azabicyclo[2.2.2]octan-3-amine
• 8-[4-(4-FLUOROPHENYL)-4-OXOBUTYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4,5]DECAN-4-ONE HYDROCHLORIDE
• 1-(3-NITROPYRIDIN-2-YL)PIPERIDINE-4-CARBOXAMIDE
• 8-acetyl-3-dodecyl-7,7,9,9-tetramethyl-1,3,8-triazaspiro[4.5]decane-2,4-dione
• N-METHYL-8-[4-(4-FLUOROPHENYL)-4-OXOBUTYL]-1-PHENYL-1,3,8-TRIAZASPIRO-[4.5]DECAN-4-ONE HYDROCHLORIDE
• 2'H,5'H-spiro[4-azabicyclo[2.2.2]octane-2,4'-imidazolidine]-2',5'-dione
• TIMTEC-BB SBB004248
• 1-(2-PYRIMIDINYL)-4-PIPERIDINECARBOXAMIDE
• 1-[5,7-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDIN-2-YL]-4-PIPERIDINECARBOXAMIDE