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7-Fluoroindole

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7-Fluoroindole Basic information

Product Name:
7-Fluoroindole
Synonyms:
  • BUTTPARK 24\07-35
  • 7-FLUOROINDOLE
  • 7-FLUORO-1H-INDOLE
  • 1H-Indole, 7-fluoro-
  • 7-ETHOXYINDOLE
  • 7-Fluoroindoline-2-one
  • 7-Fluoroindole,97%
  • 6-(2-(diMethylaMino)vinyl)-5-nitropyriMidine-2,4(1H,3H)-dione
CAS:
387-44-0
MF:
C8H6FN
MW:
135.14
EINECS:
640-248-2
Product Categories:
  • Building Blocks
  • C7 to C10
  • C7 to C9
  • Chemical Synthesis
  • Fluorinated Building Blocks
  • Halogenated Heterocycles
  • Indoles
  • Simple Indoles
  • Fluorinated heterocyclic series
  • Heterocyclic Building Blocks
  • Heterocyclic Fluorinated Building Blocks
  • New Products for Chemical Synthesis
  • Other Fluorinated Heterocycles
  • Fluorine series
  • Indoles and derivatives
  • Indole
Mol File:
387-44-0.mol
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7-Fluoroindole Chemical Properties

Melting point:
61 °C
Boiling point:
258.0±13.0 °C(Predicted)
Density 
1.273±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in methanol. (almost transparency)
pka
15.55±0.30(Predicted)
form 
powder to crystal
color 
White to Light yellow to Light orange
BRN 
114740
InChIKey
XONKJZDHGCMRRF-UHFFFAOYSA-N
CAS DataBase Reference
387-44-0(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-41-37/38-22
Safety Statements 
26-36-39
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29339900

MSDS

  • Language:English Provider:ALFA
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7-Fluoroindole Usage And Synthesis

Chemical Properties

Brown solid

Uses

7-Fluoroindole is a reagent used in chemical synthesis. It has been used to synthesize antiviral compounds against Pseudomonas aeruginosa and Staphylococcus aureus along with creation of immunomodulators. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

Antimicrobial activity

7-fluoroindole (7FI) was identified as a compound that inhibits biofilm formation and blood hemolysis without inhibiting the growth of planktonic P. aeruginosa cells. Moreover, 7FI markedly reduced the production of quorum-sensing (QS)-regulated virulence factors 2-heptyl-3-hydroxy-4(1H)-quinolone, pyocyanin, rhamnolipid, two siderophores, pyoverdine and pyochelin. 7FI clearly suppressed swarming motility, protease activity and the production of a polymeric matrix in P. aeruginosa. However, unlike natural indole compounds, synthetic 7FI did not increase antibiotic resistance. Therefore, 7FI is a potential candidate for use in an antivirulence approach against persistent P. aeruginosa infection.

7-Fluoroindole Preparation Products And Raw materials

Raw materials

7-FluoroindoleSupplier

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